Search for dissertations about: "purpura"

Showing result 1 - 5 of 15 swedish dissertations containing the word purpura.

  2. 1. Studies of the pathogenesis of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

    Author : Diana Karpman; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatri; Pediatrics; tumor necrosis factor; interleukin 6; von Willebrand factor; apoptosis; lipopolysaccharide; shiga-like toxin; Escherichia coli O157:H7; Hemolytic uremic syndrome; thrombotic thrombocytopenic purpura; Urology; nephrology; Urologi; nefrologi;

    Abstract : This study investigated the pathogenesis of hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). (1) The relative roles of lipopolysaccharide and Shiga-like toxin-2 were studied in a mouse model of Escherichia coli O157:H7 infection. READ MORE

  4. 2. ADAMTS13 phenotype in health and disease with special reference to thrombotic thrombocytopenic purpura

    Author : Minola Manea Hedström; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; tubular cells; podocytes; kidney; plasma; ADAMTS13; thrombotic thrombocytopenic purpura; nephrology; Urologi; nefrologi; Pediatrics; Pediatri;

    Abstract : Von Willebrand factor (VWF) is synthesized and secreted by endothelial cells into the plasma as a series of multimers. VWF induces the formation of platelet plugs at sites of vascular injury and high shear stress. Biological activity is dependent on multimeric size, which is regulated in plasma by the VWF-cleaving protease ADAMTS13. READ MORE

  5. 3. Studies of the pathogenesis of IgA nephropathy and Henoch-Schönlein purpura, with special reference to Streptococcus pyogenes infections and complement

    Author : Roland Schmitt; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgA nephropathy; Henoch-Schönlein purpura; Streptococcus pyogenes; M protein; complement;

    Abstract : IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis and Henoch-Schönlein purpura (HSP) the most common form of vasculitis in childhood. HSP may affect kidneys, a complication termed Henoch-Schönlein nephropathy (HSN). Renal pathology in HSN resembles that seen in IgAN. The pathogenesis of IgAN and HSP is so far unclear. READ MORE

  6. 4. Idiopathic thrombocytopenic purpura in childhood : clinical features, diagnostics and treatment

    Author : Iris Treutiger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Idiopathic thrombocytopenic purpura; childhood; treatment; morbidity; outcome; T cell expansion; T cell receptor;

    Abstract : Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by thrombocytopenia, i.e. platelet count (pl.c. READ MORE

  7. 5. On cellular immunology in chronic idiopathic thrombocytopenic purpura (ITP)

    Author : Per-Ola Andersson; Göteborgs universitet; []
    Keywords : chronic ITP; T-cells; TGF-b1; Th3; cell-mediated cytotoxicity; KIR; DNA microarray;

    Abstract : Chronic idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disease characterized by a low platelet count and mucocutaneous bleedings. Chronic ITP is considered to be mediated by autoantibodies leading to premature destruction of platelets in the reticuloendothelial system. READ MORE