Search for dissertations about: "pxr"
Showing result 1 - 5 of 12 swedish dissertations containing the word pxr.
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1. Chemical mixtures and interactions with detoxification mechanisms and biomarker responses in fish
Abstract : Several classes of anthropogenic chemicals are present as mixtures in the aquatic environment. However, information of how wildlife species, including fish, are affected by exposures to chemical mixtures is limited. READ MORE
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2. Studies on nuclear receptors involved in drug metabolism
Abstract : The molecular basis for drug metabolism is starting to emerge as a result of cloning and characterization of a group of nuclear receptors that respond to drugs by transcriptional regulation of key genes encoding enzymes involved in metabolism of commonly used drugs. This thesis describes the identification and functional, as well as the structural, characterization of one of these receptors, the human pregnenolone activated receptor (hPAR, NR1I2) that also has been referred to as the pregnane X receptor (PXR) or the steroid and xenobiotic receptor (SXR) by others. READ MORE
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3. Cytochrome P450 in the rat brain : characterization and regulation
Abstract : Cytochrome P450s (CYPs) are key enzymes in the metabolism of cholesterol and fatty acids and their derivatives in the body. In the adrenals and gonads these enzymes are involved in steroid hormone biosynthesis, in the liver in bile acid synthesis, in the kidney in synthesis of the calcitropic hormone, calcitriol, and in the cardiovascular system in synthesis of thromboxane A2, a potent inducer of vasoconstriction and platelet aggregation. READ MORE
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4. Determinants of ligand-induced nuclear receptor activation
Abstract : The nuclear receptors (NRs) constitute a highly conserved superfamily of transcription factors restricted to metazoans. In general, these receptors are regulated by small lipophilic molecules such as steroids, thyroid hormones and retinoids and play an important role in cellular regulation. READ MORE
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5. Novel human in vitro systems for studies of drug inducted hepatotoxicity
Abstract : Drug-induced liver injury (DILI) is a major human health concern, estimated to account for about half of all cases of acute liver failure in the general population. DILI also represents a significant problem in drug discovery, being one of the most common reasons for regulatory actions, including boxed warnings, restricted marketing and withdrawals of marketed drugs. READ MORE
