Search for dissertations about: "pyrimidine metabolism"

Showing result 1 - 5 of 7 swedish dissertations containing the words pyrimidine metabolism.

  2. 1. Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei

    Author : Munender Vodnala; Anders Hofer; Arne Holmgren; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Trypanosoma brucei; adenosine kinase; thymidine kinase; methylthioadenosine phosphorylase; mouser ribonucleotide reductase; E. coli ribonucleotide reductase; RNR; Ara-A; F-Ara-A; dNTP; NTP; doexynucleotide metabolism; nucleosides; nucleoside kinases; allosteric regulation; biologisk kemi; biological chemistry;

    Abstract : Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs.T. READ MORE

  4. 2. Reconstitution of Membrane-Bound Enzymes for Neutron Scattering Studies: A Case Study of Human Dihydroorotate Dehydrogenase

    Author : Manuel Orozco; Molekylär cellbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; membrane proteins; dihydroorotate dehydrogenase; pyrimidine metabolism; neutron scattering; ubiquinone; QCM-D;

    Abstract : Membrane proteins are challenging to study due the necessity to maintain a lipid-like environment to preserve their structure and function. Particularly difficult to study are membrane-bound enzymes that interact with lipophilic substrates. READ MORE

  5. 3. Catabolism of Pyrimidines in Yeast

    Author : Anna Rasmussen; Molekylär cellbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Pyrimidine degradation; catabolism of pyrimidines; nucleic acid precursors; yeast; Lachancea kluyveri; URC pathway;

    Abstract : Pyrimidines are important precursors for nucleic acids, and constantly synthesized and degraded in the cell to maintain a balanced supply. Many microoganisms can also extract the nitrogens from the pyrimidine ring, and use them as a nitrogen source when “preferred” sources are absent. READ MORE

  6. 4. Towards an Earlier Detection of Progressive Multiple Sclerosis using Metabolomics and Machine Learning

    Author : Stephanie Herman; Kim Kultima; Ola Spjuth; Joachim Burman; Johan Lengqvist; Camilla Svensson; Gabi Kastenmüller; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bioinformatics; biomarkers; progressive multiple sclerosis; metabolomics; machine learning; advanced analytics; mass spectrometry;

    Abstract : Decision-making guided by advanced analytics is becoming increasingly common in many fields. Implementing computationally driven healthcare solutions does, however, pose ethical dilemmas as it involves human health. READ MORE

  7. 5. Metabolic regulation and anticancer drug resistance in the yeast Saccharomyces cerevisiae

    Author : Mattias Carlsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer is a malignant neoplastic tissue. The pyrimidine analogue 5-fluorouracil is an anticancer drug used against several types of cancer. It owes its specificity against neoplasms due to the higher rate of nutrient uptake, RNA and DNA synthesis, and in particular the higher rate of nucleobase scavenging and salvage of neoplastic cells. READ MORE