Search for dissertations about: "quantitation"

Showing result 1 - 5 of 59 swedish dissertations containing the word quantitation.

  1. 1. Quantitative Bioanalysis : Liquid separations coupled to targeted mass spectrometric measurements of bioactive compounds

    Author : Björn Arvidsson; Jonas Bergquist; Magnus Wetterhall; Gérard Hopfgartner; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Analytical chemistry; Method development; Enhanced microdialysis; Column switching; Liquid chromatography; Capillary electrophoresis; Electrospray ionization; Mass spectrometry; Triple quadrupole; Time-of-flight; Quantitation; Validation; Analytisk kemi;

    Abstract : Performing quantitative analysis of targeted bioactive compounds in biological samples, such as blood plasma, cerebrospinal fluid or extracts from pig liver, put high demands on the ruggedness of the method acquiring the results. In addition to the complexity of the sample matrix, the bioactive compounds targeted for analysis usually have low levels of natural abundance, further increasing the demand on the analytical method sensitivity. READ MORE

  2. 2. Quantitation of gluconeogenesis in humans

    Author : Karin Ekberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Gluconeogenesis; mass isotopomer distribution analysis; deuteratedwater; hexamethylenetetramine; splanchnic and renal glucose production;

    Abstract : Quantitation of Gluconeogenesis in Humans by Karin Ekberg, Department of Clinical Physiology, Karolinska Hospital and Institute,S-171 76 Stockholm, Sweden Several methods have been introduced for estimating gluconeogenesis, but noneprovides a direct measurement without assumptions that condition the accuracy ofthe estimate. The aim of this work has been to develop a new method for quantitativestudies of gluconeogenesis, applicable in humans. READ MORE

  3. 3. Development and Application of Software Tools for Mass Spectrometry Imaging

    Author : Patrik Källback; Per E. Andrén; Per Svenningsson; Anna Nilsson; Benjamin Bowen; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; DESI; msIQuant; quantitation; neurotransmitters; drugs; derivatization; brain; compression; data entropy reduction;

    Abstract : Mass spectrometry imaging (MSI) has been extensively used to produce qualitative maps of distributions of proteins, peptides, lipids, neurotransmitters, small molecule pharmaceuticals and their metabolites directly in biological tissue sections. Moreover, during the last 10 years, there has been growing demand to quantify target compounds in tissue sections of various organs. READ MORE

  4. 4. Metabolic Studies with Liquid Separation Coupled to Mass Spectrometry

    Author : Erik Allard; Jonas Berguist; Per Sjöberg; Risto Kostiainen; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; liquid chromatography; mass spectrometry; tandem mass spectrometry; method development; capillary electrophoresis; electrospray ionization; time-of-flight; quantitation; metabolomics; metabonomics; pattern recognition; ximelagatran; melagatran; charge state; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Abstract : Metabolism is the sum of all chemical processes with the purpose to maintain life, as well as enable reproduction, in a living organism. Through the study of metabolism, increased understanding of pharmacological mechanisms and diseases can be achieved. READ MORE

  5. 5. Solid-Phase Microextraction in Polymer Analysis - Extraction of Volatiles from Virgin and Recycled Polyamide 6.6

    Author : Mikael Gröning; Minna Hakkarainen; Stephen Kelley; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Chemistry; polymer; polyamide 6.6; volatiles; emissions; degradation; quantitation; Kemi; Chemistry; Kemi;

    Abstract : The extraction and quantitative analysis of low molar mass compounds in polymers is an analytical challenge. It is also important from a practical point of view because the low molar mass compounds in time will migrate from the polymers into the surrounding environment. READ MORE