Search for dissertations about: "quantitative RT-PCR"

Showing result 1 - 5 of 72 swedish dissertations containing the words quantitative RT-PCR.

  1. 1. Qualitative and Quantitative Assessment of Cytochromes P450 mRNA in Human Studies in the Liver, Blood and Gastrointestinal Mucosa

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mari Thörn; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; cytochrome P450; CYP1A2; CYP1B1; CYP2E1; CYP3A4; CYP3A5; P-gp; gene expression; RT-PCR; liver; blood; gastrointestinal mucosa; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

    Abstract : Drugs and other foreign compounds must often be metabolised before they can be excreted from the body. One enzyme system that is responsible for this is the cytochrome P450 gene family (CYP). READ MORE

  2. 2. Radiolabelled Oligonucleotides for Evaluation of in vivo Hybridisation Utilising PET Methodology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Gábor Lendvai; Uppsala universitet.; [2007]
    Keywords : Molecular medicine; Gene expression; Antisense oligonucleotides; Positron emission tomography; In vivo hybridisation; In vivo biodistribution; Chromogranin-A; 68Ga; RT-PCR; Scavenger receptors; Molekylärmedicin;

    Abstract : Antisense oligonucleotides (ODN) may interfere in gene expression on the basis of hybridising to its complementary messenger RNA (mRNA) sequence in the cell thereby preventing the synthesis of the peptide. Therefore, these ODNs may be potential drugs to treat human diseases by “knocking down” the expression of responsible genes or correcting the maturation process of mRNA in the field called antisense therapy. READ MORE

  3. 3. Vascular endothelial growth factor in renal cell carcinoma

    University dissertation from Umeå : Kirurgisk och perioperativ vetenskap

    Author : Jan Jacobsen; Umeå universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; VEGF; isoforms; quantitative RT-PCR; immunohistochemistry; tissue microarray; Western blot; stage; survival; renal cell carcinoma; MEDICINE Surgery Surgical research Urology and andrology; MEDICIN Kirurgi Kirurgisk forskning Urologi och andrologi;

    Abstract : Background. Angiogenesis is essential for tumour growth. Vascular endothelial growth factor (VEGF) and its isoforms were investigated in relation to the clinical course in a large number of patients with renal cell carcinoma (RCC).Methods. READ MORE

  4. 4. Methodological studies of eicosanoid enzyme gene expression in vascular endothelium exposed to biomechanical stress

    University dissertation from Göteborg

    Author : Roya Doroudi; Göteborgs universitet.; Gothenburg University.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostanoids; endothelium; quantitative RT-PCR; perfusion model; shear stress; intraluminal pressure; immediate-early genes;

    Abstract : Prostaglandins are the major eicosanoids synthesized by vascular endothelial cells, and the vasculature is an important target organ for their bioactive metabolites. In vitro studies have shown that biomechanical forces are important regulators of vascular expression of prostanoid enzymes and release of metabolites. READ MORE

  5. 5. Islet Xenotransplantation An Experimental Study of Barriers to Clinical Transplantation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Peter Schmidt; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; xenotransplantation; islets of Langerhans; rejection; diabetes; porcine endogenous retroviruses; quantitative RT-PCR; cytokines; animal models; Medicin; MEDICINE Dermatology and venerology; clinical genetics; internal medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : In the field of transplantation, the increasing deficit of human donors have lead to an interest in animals as an alternative source of organs and tissues. Different in vitro systems and rodent models of xenotransplantation were used to examine the most significant barriers that have to be overcome, before isolated islets of Langerhans from pigs can be used as a cure for insulin-dependent diabetes mellitus in humans. READ MORE