Search for dissertations about: "quiescent cells"

Showing result 1 - 5 of 40 swedish dissertations containing the words quiescent cells.

  1. 1. Function and Regulation of B-cell Subsets in Experimental Autoimmune Arthritis

    Author : Anna-Karin E. Palm; Sandra Kleinau; Susanna Cardell; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; B cells; marginal zone; autoimmune arthritis; spleen; lymph node; antigen presentation; Fc gamma receptor IIb; complement receptors 1 and 2; mast cells; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Immunology;

    Abstract : B lymphocytes play a significant role in autoimmune arthritis, with their function stretching beyond autoantibody production to cytokine secretion and presentation of autoantigen. However, the involvement and activation of different B-cell subset in the autoimmune response is not fully clear. READ MORE

  2. 2. Sampling from large flotation cells : An invastigation of spatial distribution

    Author : Lisa Malm; Jan Rosenkranz; Tommy Karlkvist; Anders Sand; Nils-Johan Bolin; Pertti Lamberg; Luleå tekniska universitet; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; ENGINEERING AND TECHNOLOGY; Flotation; sampling; Mineral Processing; Mineralteknik;

    Abstract : The general trend in flotation technology today is towards larger flotation cells, which enables a higher throughput. However, adverse effects such as segregation and reduced froth transport efficiency have also been observed in larger cells. READ MORE

  3. 3. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities

    Author : Wojciech Senkowski; Mårten Fryknäs; Rolf Larsson; Peter Nygren; Mats Gustafsson; Krister Wennerberg; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; spheroids; high-throughput screening; nitazoxanide; OXPHOS; gene expression profiling; statins; drug repositioning; 3D cell culture; quiescent cells; Medical Science; Medicinsk vetenskap;

    Abstract : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. READ MORE

  4. 4. The Role of Kit and Thrombopoietin in Regulation of Hematopoietic Stem Cells

    Author : Lina Thorén; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thrombopoietin; hematopoiesis; Thpo; c-kit; stem cells;

    Abstract : The hematopoietic stem cell (HSC) is postulated to be the ultimate hematopoietic precursor providing production of mature blood cells, and is characterized by a life long capacity for self-renewal and multilineage differentiation. In a healthy human, the HSC produces 1,000,000,000,000 cells per day, illustrating the high turnover within the hematopoietic system and the need for replenishments by HSCs. READ MORE

  5. 5. Satellite cells in human skeletal muscle : molecular identification quantification and function

    Author : Mona Lindström; Lars-Eric Thornell; Hannu Kalimo; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; satellite cell markers; NCAM; Pax7; MyoD; myogenin; DLK1 FA1; c-Met; human skeletal muscle; immunohistochemistry; muscle growth; muscle hypertrophy; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; anatomi; Human Anatomy;

    Abstract : Skeletal muscle satellite cells located between the plasma membrane and the basal lamina of muscle fibres, could for many years, only be studied in situ by electron microscopy. The introduction of immunohistochemistry and the discovery of molecular markers of satellite cells then made them accessible for light microscopic studies and a wealth of information is today available. READ MORE