Search for dissertations about: "quinolinic acid"

Showing result 1 - 5 of 8 swedish dissertations containing the words quinolinic acid.

  2. 1. Tryptophan-related Neurotransmission in the Brain: Disturbances Associated with Experimental Hepatic Encephalopathy

    Author : Peter B F Bergqvist; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tetrodotoxin; serotonin; release; rat; quinolinic acid; potassium; chloroamphetamine; noradrenaline; neurotransmission; microdialysis; hepatic encephalopathy; fenfluramine; drug safety; dopamine; coma; citalopram; ammonia; calcium; brain; tryptophan; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : In the present study, L-tryptophan (TRP)-related disturbances in the brain in experimental hepatic encephalopathy (HE) were investigated. The endogenous NMDA-receptor agonist and L-TRP metabolite quinolinic acid (QUIN) has been suggested to be involved in the pathogenesis of HE. READ MORE

  4. 2. Dysregulation of the kynurenine pathway in psychotic disorders : immunological aspects

    Author : Magdalena Kegel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Kynurenic acid (KYNA), a metabolite of the kynurenine pathway, is emerging as a key factor in the development of psychotic disorders. Increased levels of KYNA are found in the brain and cerebrospinal fluid (CSF) of patients with schizophrenia and bipolar disorder, and are associated to psychotic symptoms. READ MORE

  5. 3. The kynurenine pathway in body and brain : relation with physical exercise and mental health

    Author : Ada Trepci; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The kynurenine pathway of tryptophan degradation is the focus in a variety of research fields and several of the metabolites produced along the pathway are suggested as future biomarkers. Growing interest in a better understanding of the physiological and the pathophysiological importance of kynurenine pathway metabolites is followed by the need for a robust, sensitive method that can quantify multiple metabolites simultaneously. READ MORE

  6. 4. Immunological and Inflammtory Responses against Intrastriatal Neural Grafts in the Rat

    Author : Wei-Ming Duan; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; MHC; Rat; Brain; Xenogeneic; Allogeneic; Syngeneic; Cytokine; Inflammation; Neural transplantation; Immunology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Intracerebral neural transplantation offers a new strategy to combat Parkinson’s and Huntington’s diseases. However, a host immune response against a histoincompatible neural graft in the brain may jeopardize transplant survival. READ MORE

  7. 5. Effects of dopamine and excitotoxicity in experimental models of Huntington's disease

    Author : Åsa Petersén; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; excitotoxicity; dopamine; Huntington s disease; striatum; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the HD gene, that leads to dysfunction and death of striatal neurons. The pathogenetic mechanisms underlying HD are not known, but excitotoxicity and dopamine (DA) have been suggested to play a role. READ MORE