Search for dissertations about: "ra modeling"

Found 5 swedish dissertations containing the words ra modeling.

2. 1. Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes

   Author : Ida E. Andersson; Jan Kihlberg; Anna Linusson Jonsson; Craig Crews; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Major histocompatibility complex; class II MHC; T-cell receptor; rheumatoid arthritis; collagen-induced arthritis; glycopeptide; amide bond isostere; comparative modeling; rational design; molecular docking; molecular dynamics simulation; statistical molecular design; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry; Biorganic Chemistry; bioorganisk kemi; datorlingvistik; computational linguistics;

   Abstract : Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell receptors (TCRs) recognize a complex between the class II MHC Aq protein and CII259-273, a glycopeptide epitope from type II collagen (CII). READ MORE

4. 2. Generation of cell diversity in the developing brainstem and its modeling in vitro

   Author : Mariya Kozhevnikova; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The intersection of spatial and temporal patterning programs underlies the formation of neural cell type diversity in the developing central nervous system (CNS). Deciphering the molecular mechanisms regulating positional and temporal patterning provides a basic framework for how the developing brain can be functionally assembled, and the growing knowledge about these patterning mechanisms offer a powerful tool to effectively control the differentiation of pluripotent stem cells (PSCs) into different neuronal subtypes of clinical importance. READ MORE

5. 3. Quantitative genetics of wood quality traits in Scots pine

   Author : Irena Fundová; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Abstract : Wood quality of commercial tree species is important for many wood processingindustries and thus should be considered for inclusion in forest tree improvementprograms. This thesis evaluated the suitability of various proxy methods for rapid andnon-destructive assessment of wood quality traits on standing trees of Scots pine and thepotential for genetic improvement of different wood quality traits through recurrentselective breeding. READ MORE

6. 4. Learning to guide behavior change : physical therapists’ promotion of health-enhancing physical activity in people with rheumatoid arthritis

   Author : Thomas Nessen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background and Aim: Physical activity is important for management of rheumatoid arthritis (RA). In the Physical Activity in RA (PARA) 2010 study physical therapists (PTs) delivered a one-year health-enhancing physical activity (HEPA) intervention in people with RA. READ MORE

7. 5. Security and Privacy of Sensitive Data in Cloud Computing

   Author : Ali Gholami; Erwin Laure; Seif Haridi; Schahram Dustdar; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Cloud Computing; Security; Privacy; Trust; Opertaing System; Computer Science; Datalogi;

   Abstract : Cloud computing offers the prospect of on-demand, elastic computing, provided as a utility service, and it is revolutionizing many domains of computing. Compared with earlier methods of processing data, cloud computing environments provide significant benefits, such as the availability of automated tools to assemble, connect, configure and reconfigure virtualized resources on demand. READ MORE