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Showing result 1 - 5 of 188 swedish dissertations matching the above criteria.

2. 1. Cellular effects of ionizing radiation : Relevant for understanding cancer risk after medical and environmental radiation exposures

   Author : Pamela Chiaka Akuwudike; Andrzej Wojcik; Lovisa Lundholm; Kerstin Borgmann; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation; DNA damage; radiation-induced carcinogenesis; second primary cancer; cisplatin chemoradiotherapy; dose fractionation; low dose; low dose rate; dose and dose rate effectiveness factor DDREF ; molekylär biovetenskap; Molecular Bioscience;

   Abstract : Radiation-induced cancers are stochastic and delayed effects of exposure to ionizing radiation. The dose-response relationship for radiation-induced cancers at both low dose/low dose rates and high doses (doses encountered during radiotherapy) remains unclear. READ MORE

4. 2. Accurate description of heterogeneous tumors for biologically optimized radiation therapy

   Author : Johan Nilsson; Bengt Lind; Anders Brahme; Margareta Edgren; Søren Bentzen; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heterogeneous tumors; radiation therapy; biological optimization; tumor hypoxia; effective radiation sensitivity; effective radiation resistance; Radiation biology; Strålningsbiologi;

   Abstract : In this thesis, a model of tissue oxygenation is presented, that takes into account the heterogeneous nature of tumor vasculature. Even though the model is rather simple, the resulting oxygen distributions agree very well with clinically observed oxygen distributions for most tumors and healthy normal tissues. READ MORE

5. 3. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

   Author : Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

   Abstract : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. READ MORE

6. 4. Ethical aspects of radiation protection

   Author : Per Wikman-Svahn; John Cantwell; Gustaf Arrhenius; KTH; []
   Keywords : HUMANIORA; HUMANITIES; Radiation; risk; ethics; Philosophy subjects; Filosofiämnen;

   Abstract : This aim of this thesis is to examine ethical aspects of radiation protection from ionizing radiation. Radiation protection is the professional field that deals with the protection of humans and the environment from the harmful effects of radiation. READ MORE

7. 5. Radiation induced biomarkers of individual sensitivity to radiation therapy

   Author : Sara Skiöld; Mats Harms-Ringdahl; Siamak Haghdoost; Mats Ljungman; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; low dose ionizing radiation; radiation sensitivity; proteomics; whole blood; 8-oxo-dG; oxidative stress; acute adverse healthy tissue effects; molekylär biovetenskap; Molecular Bioscience;

   Abstract : Fifty percent of solid cancers are treated with radiation therapy (RT). The dose used in RT is adjusted to the most sensitive individuals so that not more than 5% of the patients will have severe adverse healthy tissue effects. READ MORE