Search for dissertations about: "radiobiological modelling"

Showing result 6 - 9 of 9 swedish dissertations containing the words radiobiological modelling.

  2. 6. Contouring variability in radiosurgery - dosimetric and radiobiological implications

    Author : Helena Sandström; Iuliana Toma-Dasu; Mike Partridge; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Medical Radiation Physics; medicinsk strålningsfysik;

    Abstract : The use of Stereotactic Radiation Therapy (SRT) employing one large fraction of radiation, as in stereotactic radiosurgery (SRS), or few fractions of high doses, has continuously increased due to the technical development and the progress in dose delivery complemented by the positive clinical experience. The success of stereotactic radiation therapy depends on many clinical, dosimetric and radiobiological factors. READ MORE

  4. 7. Biological effects of high energy radiation and ultra high dose rates

    Author : Björn Zackrisson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiobiology; 50 MV x-rays; 50 MeV electrons; in vitro; in vivo; RBE; OER; ultra high dose-rate; radiobiological models; model selection; models of stochastic processes;

    Abstract : Recently a powerful electron accelerator, 50 MeV race-track microtron, has been taken into clinical use. This gives the opportunity to treat patients with higher x-ray and electron energies than before. Furthermore, treatments can be performed were the entire fractional dose can be delivered in parts of a second. READ MORE

  5. 8. The virtual tumour - in silico modelling of tumour vasculature, oxygenation and treatment outcome

    Author : Filippo Schiavo; Iuliana Toma-Daşu; Emely Kjellsson Lindblom; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Medical Radiation Physics; medicinsk strålningsfysik;

    Abstract : Poor tumour oxygenation, namely hypoxia, is one of the major challenges that has been recognised in radiotherapy, yet it is not being accounted for in standard treatments. Hypoxia, resulting from a heterogeneous distribution of vessels (chronic hypoxia) or of a loss in vascular perfusion (acute hypoxia), affects all kinds of solid tumours to different extents. READ MORE

  6. 9. Micro/nanometric Scale Study of Energy Deposition and its Impact on the Biological Response for Ionizing Radiation : Brachytherapy radionuclides, proton and carbon ion beams

    Author : Fernanda Villegas Navarro; Anders Ahnesjö; Carmen Villagrasa; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ionizing radiation; Monte Carlo track structure code; Microdosimetric spread; Energy deposition clustering; RBE; Medicinsk radiofysik; Medical Radiophysics;

    Abstract : Research in radiotherapy for cancer treatment focuses on finding methods that can improve the compromise between tumour cell inactivation versus damage to the surrounding healthy tissue. As new radiation modalities such as proton therapy become accessible for everyday clinical practice, a better understanding of the variation in biological response of the tumour and healthy tissues would improve treatment planning to achieve optimal outcome. READ MORE