Search for dissertations about: "radionuclide THESIS"
Showing result 1 - 5 of 166 swedish dissertations containing the words radionuclide THESIS.
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1. Two-Step Targeting for Effective Radionuclide Therapy : Preclinical Evaluation of 125I-labelled Anthracycline Delivered by Tumour Targeting Liposomes
Abstract : For the treatment of cancer, Auger-electron emitting radionuclides are strongly dependent on their close proximity to DNA to utilize the local therapeutic potential of the Auger electrons. This thesis investigates a two-step targeting approach that uses targeting liposomes for the delivery of an Auger-electron emitter, 125I, coupled to a DNA-binding compound, Comp1, to the tumour-cell DNA. READ MORE
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2. Antibody-Based Radionuclide Targeting for Diagnostics and Therapy : Preclinical Studies on Head and Neck Cancer
Abstract : Antibody-based targeting techniques play an increasingly important role in cancer research. By targeting a structure that is abundant in tumour cells, but rare in healthy tissues, an antibody can mediate the delivery of radioactivity specifically to tumour cells in the body. READ MORE
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3. Development of Affibody molecules for radionuclide molecular imaging and therapy of cancer
Abstract : Affibody molecules are a promising class of scaffold-based targeting proteins for radionuclide-based imaging and therapy of cancer. This thesis work is based on 5 original research articles (papers I-V), which focus on optimization of molecular design of HER2-binding Affibody variants for high contrast imaging of this predictive biomarker as well as development of Affibody molecules suitable for radionuclide-based targeted therapies. READ MORE
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4. Radionuclide Production with PET Cyclotrons, Applications and Preclinical Experiments
Abstract : Nuclear medicine is based on the radiotracer principle of George de Hevesy and the magic bullet concept by Ehrlich and focuses on the diagnosis, the treatment of diseases and the investigation of normal states within the human body using radiopharmaceuticals. A radiopharmaceutical is an atom or a chemical compound in which one or several atoms are replaced with a radionuclide. READ MORE
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5. Internal Dosimetry Development and Evaluation of Methods and Models
Abstract : Radionuclide therapy requires patient-specific planning of the absorbed dose to target volumes, in most cases tumours, in order to achieve an expected biological effect, taking into account that the absorbed doses to normal organs and tissues should be kept as low as reasonably achievable. Therefore, the calculation of absorbed doses has to be as accurate as possible. READ MORE
