Search for dissertations about: "radiotherapy and prognosis"

Showing result 1 - 5 of 108 swedish dissertations containing the words radiotherapy and prognosis.

2. 1. Towards improved oncological treatment of esophageal and gastric cancer. Clinical and translational studies

   Author : David Borg; Tumörmikromiljö; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal adenocarcinoma; Gastric cancer; PODXL; Prognosis; Prediction; Chemotherapy dose intensity; Dysphagia; Radiotherapy;

   Abstract : BackgroundThe overall aim of this thesis was to improve the oncological treatment strategies in esophageal and gastric adenocarcinoma (EGAC). Podocalyxin-like protein 1 (PODXL) has been associated with poor prognosis in other cancers and we wanted to investigate its potential role as a prognostic and predictive biomarker in resectable EGAC. READ MORE

4. 2. Glioblastoma heterogeneity and plasticity : Investigating the roles of BMP4 and SOX2

   Author : Erika Dalmo; Bengt Westermark; Fredrik J. Swartling; Lene Uhrbom; Ana Martin-Villalba; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; SOX2; BMP4; senescence; plasticity; Oncology; Onkologi; Medicinsk vetenskap; Medical Science; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Abstract : The malignant primary brain tumor glioblastoma has a dismal prognosis and is distinguished by its heterogeneous character. Current treatment with surgical resection, radiotherapy and adjuvant chemotherapy with the alkylating agent temozolomide does not provide a cure, but simply prolongs survival by a few months. READ MORE

5. 3. Bystander Cells and Prognosis in Hodgkin Lymphoma

   Author : Daniel Molin; Stephen J. Proctor; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Hodgkin Lymphoma; Bystander cells; Eosinophilic granulocytes; Eosinophil cationic protein ECP ; Mast cells; Prognosis; Early and Intermediate stage; Onkologi; Hodgkin lymfom; eosinofila granulocyter; ECP; mast celler; prognos; tidiga och intermediära stadier; Oncology; Onkologi; Oncology; onkologi;

   Abstract : Hodgkin lymphoma (HL) is characterised histologically by a minority of malignant Hodgkin and Reed-Sternberg (HRS) cells surrounded by benign cells, and clinically by a relatively good prognosis. The treatment, however, leads to a risk of serious side effects. READ MORE

6. 4. Staging and therapy response in rectal cancer

   Author : Klara Hammarström; Tobias Sjöblom; Bengt Glimelius; Artur Mezheyeuski; Eva Angenete; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rectal cancer; radiotherapy; chemoradiotherapy; complete remission; response prediction; prognosis; targeted sequencing; Medicinsk vetenskap; Medical Science;

   Abstract : Every year, around 2,200 individuals are diagnosed with rectal cancer in Sweden. As a result of better tumour staging using magnetic resonance imaging (MRI), pre-operative radiotherapy (with or without chemotherapy), and improved surgery, outcome has improved substantially during the past few decades. READ MORE

7. 5. Experimental and population-based studies on colorectal cancer - Thymidine phosphorylase as a potential biomarker

   Author : Elinor Bexe-Lindskog; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; thymidine phosphorylase; chemotherapy; adjuvant; biological markers; prognosis; practice guidelines; radiotherapy;

   Abstract : Background: Colorectal cancer (CRC) is one of the most common malignancies, and the only reliable treatment option for cure is surgery. Method: Quantitative real-time polymerase chain reaction was used to analyze the gene expression of the enzyme thymidine phosphorylase (TP), which was related to prognostic factors (paper I, n=254), evaluated as a predictive factor (paper III, n=125), and assessed by change of treatment (paper II, n=28). READ MORE