Search for dissertations about: "randomization in clinical trials"

Showing result 1 - 5 of 13 swedish dissertations containing the words randomization in clinical trials.

  2. 1. Optimal adaptive designs and adaptive randomization techniques for clinical trials

    Author : Yevgen Ryeznik; Warwick Tucker; Andrew Hooker; Franz König; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; optimal designs; optimal adaptive designs; randomization in clinical trials; restricted randomization; adaptive randomization; unequal cost; allocation ratio preserving randomization procedures; heterogeneous costs; multi-arm clinical trials; randomization-based inference; unequal allocation; Tillämpad matematik och statistik; Applied Mathematics and Statistics;

    Abstract : In this Ph.D. thesis, we investigate how to optimize the design of clinical trials by constructing optimal adaptive designs, and how to implement the design by adaptive randomization. READ MORE

  4. 2. Depression in teenagers and young adults : foundational studies of the new treatment paradigm TARA: Training for Awareness, Resilience, and Action

    Author : Erik Ekbäck; Eva Henje Blom; Ida Blomqvist; Jenny Molin; Inga Dennhag; Thorbjörn Lundberg; Elizabeth McCauley; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Depression; adolescents; young adults; medical students; mental health; anxiety; psychological stress; qualitative research; randomization; yoga; mindfulness; psychotherapy; antidepressant drugs; biomarkers; clinical trial; feasibility studies; online intervention; reliability; validity; confirmatory factor analysis; measurement invariance; barn- och ungdomspsykiatri; Child and Youth Psychiatry;

    Abstract : Introduction: Depression in adolescents and young adults is an increasing global health concern and available treatments are not convincingly effective. It is therefore important to develop and test novel treatments to improve treatment outcomes. READ MORE

  5. 3. On Sequential Treatment Allocations in Clinical Trials

    Author : Carl-Fredrik Burman; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; treatment assignment; clinical trial; biased coin designs; balance of prognostic factors; sequential design; randomization test; expected p-value; deficiency; efficiency; efficiency;

    Abstract : This dissertation treats baseline-dependent sequential designs of two-treatment parallel-group clinical trials. The treatment assignments are chosen in order to minimize the variance, in a linear model, of the treatment effect. This is done for each new allocation using a generalized biased coin design, or a non-randomized minimization' method. READ MORE

  6. 4. Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization

    Author : George Hindy; Diabetes - kardiovaskulär sjukdom; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; cardiovascular disease; coronary heart disease; metabolic syndrome; genetics; gene-lifestyle interactions; diet; TCF7L2; WNT signaling; chromosome 9p21; Mendelian randomization;

    Abstract : Type 2 diabetes (T2D) and cardiovascular disease (CVD) are highly prevalent complex diseases that result from lifestyle and genetic factors. Gene-lifestyle interactions are also believed to contribute to the etiology of these diseases. READ MORE

  7. 5. Philosophical controversies in the evaluation of medical treatments : With a focus on the evidential roles of randomization and mechanisms in Evidence-Based Medicine

    Author : Alexander Mebius; John Cantwell; Jeremy Howick; Sven Ove Hansson; Julian Reiss; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HUMANIORA; HUMANITIES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Evidence; randomized controlled trials; observational studies; systematic reviews; meta-analysis; methodology; process assessment; outcome assessment; medical care; randomization; evidence-based medicine; selection bias; philosophy of medicine; philosophy of science; mechanisms; quality of evidence; animal studies; treatment effect; causation by absence; medical technology; Filosofi; Philosophy;

    Abstract : This thesis examines philosophical controversies surrounding the evaluation of medical treatments, with a focus on the evidential roles of randomised trials and mechanisms in Evidence-Based Medicine. Current 'best practice' usually involves excluding non-randomised trial evidence from systematic reviews in cases where randomised trials are available for inclusion in the reviews. READ MORE