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Showing result 1 - 5 of 15 swedish dissertations matching the above criteria.

  2. 1. Premedication for intubation in newborn infants; pain assessment, pharmacokinetics and pharmacodynamics

    Author : Elisabeth Norman; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Premedication; pain; premature; newborn; aEEG; randomized controlled trial; thiopental; morphine; remifentanil; rapid sequence induction; ibntubation; pharmacokinetics; pharmacodynamics;

    Abstract : Preterm infants undergo intensive care during a vulnerable period with hemodynamic instability and a rapidly developing and immature CNS. Adequate pain management is essential, since pain experience might lead to acute physiological reactions as well as neurological and neuropsychological sequels. READ MORE

  4. 2. Assessment and management of bariatric surgery patients

    Author : Tomi Pösö; Doris Kesek; Ola Winsö; Roman Aroch; Mats Enlund; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bariatric surgery; morbid obesity; anesthesia; echocardiography; fluid therapy; preoperative; perioperative; venous return; rehydration; volatile rapid sequence induction; spontaneous breathing; sevoflurane.; anestesiologi; Anaesthesiology;

    Abstract : Background: In morbidly obese individuals (MO) cardiorespiratory comorbidities and body habitus challenge the perioperative management of anesthesia. To implement safe and reproducible routines for anesthesia and fluid therapy is the cornerstone in order to minimize anesthesia-related complications and to meet individual variability in rehydration needs. READ MORE

  5. 3. Mammalian thioredoxin reductase as a drug target in anticancer therapy through direct apoptosis induction by selenium compromised forms of the protein

    Author : Karin Anestål; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Thioredoxin reductase; TrxR1; SecTRAPs; selenoproteins; apoptosis; caspase-2; glutathione reductase; cisplatin;

    Abstract : The mammalian thioredoxin system, consisting of thioredoxin(s), thioredoxin reductase(s) and NADPH, participates in the regulation of many important systems in a mammalian cell. The mammalian thioredoxin reductases (TrxR) are selenoproteins containing a selenocysteine (Sec) residue within a carboxyl terminal -Gly -Cys -Sec -Gly -COOH motif. READ MORE

  6. 4. Clinical and physiological consequences of preoxygenation using high-flow nasal oxygen in emergency anaesthesia

    Author : Albin Sjöblom; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Airway management;

    Abstract : Emergency anaesthesia is usually performed using a rapid sequence induction technique. The incidence of desaturation during rapid sequence induction is high, and preoxygenation prolongs the safe apnoea time. READ MORE

  7. 5. A novel drug and device in anesthesia : with focus on breathing and upper airway physiology

    Author : Åse Lodenius; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Anesthesia-related airway complications are associated with hypoxia due to inability to secure or maintain the airway with subsequent insufficient ventilation and gas exchange. This thesis has explored the impact on airway integrity and respiratory regulation of two anesthetic compounds frequently used for sedation and a novel principle for oxygenation in patients at risk of hypoxia, in order to further improve patient safety during sedation and induction of anesthesia. READ MORE