Search for dissertations about: "rat brain microdialysis morris water maze"

Found 3 swedish dissertations containing the words rat brain microdialysis morris water maze.

  2. 1. The role of reactive oxygen species in traumatic brain injury : Experimental studies in the rat

    Author : Niklas Marklund; Uppsala universitet; []
    Keywords : Medical sciences; Apoptosis; CBF; controlled cortical contusion injury; 3; 4-dihydroxybenzoate; fluid percussion injury; glucose; 4-hydroxybenzoate; microdialysis; Morris Water Maze; neuroprotection; nitrones; PBN; rat; reactive oxygen species ROS ; salicylate; S-PBN; TBI; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Neurosurgery; neurokirurgi;

    Abstract : Traumatic brain injury (TBI) is a major cause of mortality and disability. As common sequelae in survivors of TBI are disabling functional, emotional and cognitive disturbances, improved treatment of TBI patients is urgently needed. At present, no neuroprotective pharmacological treatment exists. READ MORE

  4. 2. Hippocampal galanin and acetylcholine in spatial learning

    Author : Pär A Schött; Karolinska Institutet; Karolinska Institutet; []
    Keywords : hippocampus; galanin; acetylcholine; memory and learning; swim maze; microinjections; HPLC;

    Abstract : The aim of the present thesis was to study how the neuropeptide galanin affects the neurochemistry and functional activity of the cholinergic septohippocampal projection, which plays a pivotal role in learning and memory. This cholinergic system is strongly impaired in Alzheimer's disease and in age-related dementias. READ MORE

  5. 3. The hippocampal opioid system : role in spatial learning

    Author : Johan Sandin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : opioid; dynorphin; nociceptin; hippocampus; learning; memory; acetylcholine; HPLC; microinjections;

    Abstract : The main aim of the present thesis was to study the role of the endogenous hippocampal opioid system, and in particular, the role of dynorphin B and nociceptin, in spatial learning. The effects of bilateral infusion (using chronic cannulae) of dynorphin B into the dorsal hippocampus (CA3-region), an area containing a high number of dynorphin-containing neurons, were examined in the Morris swim-maze, a spatial task dependent on hippocampal functioning. READ MORE