Search for dissertations about: "reactive metabolites"

Showing result 1 - 5 of 76 swedish dissertations containing the words reactive metabolites.

  2. 1. Drug Metabolites Formed by Cunninghamella Fungi : Mass Spectrometric Characterization and Production for use in Doping Control

    Author : Axel Rydevik; Mikael Hedeland; Ulf Bondesson; David Cowan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cunninghamella blakesleeana; Cunninghamella elegans; Doping Control; Drug Metabolites; Glucuronide Production; Mass Spectrometry; Reactive Metabolites; Reference Material; Structural Characterization; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : This thesis describes the in vitro production of drug metabolites using fungi of the Cunninghamella species. The metabolites were characterized with mainly liquid chromatography-mass spectrometry using ion-trap and quadrupole-time-of-flight instruments. A fungal in vitro model has several advantages e.g. READ MORE

  4. 2. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

    Author : Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. READ MORE

  5. 3. Toxicologically important DDT metabolites : Synthesis, enantioselective analysis and kinetics

    Author : Tatiana Cantillana; Åke Bergman; Peter Sundin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; o; p -DDD; 3-Methylsulfonyl-DDE; adrenocorticolytic compounds; chiral; Environmental chemistry; Miljökemi; Environmental Chemistry; miljökemi;

    Abstract : DDT was extensively and globally used as a pesticide in agriculture and for malaria vector control from the 1940’s until the 1970’s. Due to its heavy use, DDT became ubiquitously distributed throughout the environment. DDT and several DDT metabolites are persistent organic pollutants. READ MORE

  6. 4. Electrochemical and Enzymatic In Vitro Studies on Reactive Drug Metabolites. Synthesis, Characterization and Avoidance

    Author : Tove Johansson Mali´n; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cytochrome P450; Drug; Electrochemical oxidation; Electrochemistry; Intermediate; Metabolism; Metabolic activation; Mimicry; Reactive Metabolite; Trapping.;

    Abstract : During development of pharmaceuticals, it is essential to as early as possible identify and preferably avoid formation of reactive metabolites and intermediates. Reactive metabolites may represent obstacles in the development and use of drugs, due to their potential toxicity. READ MORE

  7. 5. New Bioanalytical Approaches, Magneto Immunoassays and SIRE Technology Based Biosensors

    Author : Kirstin Kriz; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemical technology; Biokemisk teknik; antigens; superparamagnetic nanoparticles; magnetic inductance transducer; competitive magneto immunoassay; enzymes; metabolites; differential measurements; SIRE; biosensor;

    Abstract : This thesis presents two new technologies, SIRE technology based biosensors and magneto immunoassays, which can be used for bioanalytical applications. One of the main problems associated with biosensor technology is the instability of the recognition element since it is of biological origin and thus, has a limited lifetime. READ MORE