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Showing result 1 - 5 of 34 swedish dissertations matching the above criteria.

  2. 1. Congenital malformations in experimental diabetic pregnancy : Aetiology and antioxidative treatment

    Author : Martin Simán; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pregnancy; teratology; malformations; embryo; fetus; cataract; sorbitol; antioxidants; butylated hydroxytoluene; vitamin E; vitamin C; TBARS; neural crest cells; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Diabetes mellitus in pregnancy causes congenital malformations in the offspring.The aim of this work was to characterize biochemical and morphologic anomaliesin the conceptus of an animal model of diabetic pregnancy. In addition, apreventive treatment against diabetes-induced dysmorphogenesis was developed. READ MORE

  4. 2. Protection of Biomolecules by Antioxidants - Mechanisms and Applications

    Author : Carl Grey; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; dG; antioxidants; mass spectrometry; Analytical chemistry; Analytisk kemi; Food and drink technology; Livsmedelsteknik; Bioteknik; Biotechnology; DNA; Oxidation; Protein; Fenton reaction;

    Abstract : Reactive oxygen species (ROS) consisting of various oxygen-based free radicals as well as other reactive non-radical species produced in O2-related metabolism or through other processes are involved in the oxidation of such vital biomolecules as DNA, proteins and lipids. The types of oxidation represented here are known to cause many different diseases and disorders in human beings, such as cancer, Alzheimer's disease and ageing. READ MORE

  5. 3. Pathophysiological impact of targeting the ROS-p53 axis

    Author : Volkan I. Sayin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antioxidants; Cancer; p53; ROS; atherosclerosis;

    Abstract : The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using molecular biology and biochemical techniques together with mouse genetics and bioinformatics. READ MORE

  6. 4. Antioxidants as potential anti-inflammatory components in processed meat products

    Author : Stina Burri; Avdelningen för livsmedel och läkemedel; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Plant phenols; Processed meat; Colorectal cancer CRC ; Inflammation;

    Abstract : In 2015, the World health organisation (WHO) released a press statement together with the International Agency for Research in Cancer (IARC) classifying processed meat as carcinogenic. Since then, research in this area has been focused on finding the underlying mechanism(s) responsible for the link between processed meat and the increased prevalence of colorectal cancer. READ MORE

  7. 5. Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage

    Author : Faranak Azarbayjani; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Atiepileptik drugs; embryonic heart; arrhythmia; cleft palate; ROS; antioxidants; Ikr; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Abstract : The Antiepilptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), tri- and dimethadione (TMD and DMD) are known teratogens having a common malformation pattern in human and animal studies. This thesis was designed chiefly to test a hypothesis correlating the teratogenicity of these AEDs to episodes of pharmacologically induced embryonic arrhythmia and hypoxia-reoxygenation damage. READ MORE