Search for dissertations about: "rebound response"

Showing result 1 - 5 of 22 swedish dissertations containing the words rebound response.

  1. 1. Inhaled Nitric Oxide Therapy : Non-response and Rebound Response

    Author : Luni Chen; Eddie Weitzberg; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology and intensive care; nitric oxide inhalation; rebound response; non-response; endothelin-1; COX inhibitor; prostaglandin; ARDS; endotoxin; oleic acid; Anestesiologi och intensivvård; Anaesthetics and intensive care; Anestesiologi och intensivvård; Clinical Physiology; klinisk fysiologi;

    Abstract : Therapeutic inhaled nitric oxide (INO) has proved beneficial in patients with pulmonary hypertension. However, around 30-40% of the patients are non-responders to this therapy, and a life-threatening rebound response may occur during attempts to withdraw INO. READ MORE

  2. 2. Modelling of tolerance and rebound in normal and diseased rats

    Author : Christine Ahlström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : feedback modelling; tolerance; rebound; pharmacokinetics; pharmacodynamics; dyslipidaemia; nicotinic acid; non-esterified fatty acids;

    Abstract : The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, potential risks can be minimized. READ MORE

  3. 3. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres

    Author : Lena E Friberg; Mats Karlsson; Alan Boddy; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI; farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. READ MORE

  4. 4. Immune response during hepatitis B virus infection and reconstitution of HBV-specific immunity using T cells redirected against HBV

    Author : Sarene Koh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Hepatitis B is one of the most prevalent viral diseases worldwide and is a major public health concern, particularly in Asia. Of the 350 million people suffering from chronic hepatitis B virus (HBV) infection worldwide, approximately 75% are found in Asia . READ MORE

  5. 5. Effects of Seat and Seat-Belt Design on Car Occupant Response in Frontal and Rear Impacts A Study Combining Mechanical and Mathematical Modelling

    Author : Gert Nilson; Chalmers University of Technology; []
    Keywords : frontal impact; MADYMO; whiplash; rear impact; belt-in-seat; force-limiting; mathematical simulation; car seat; submarining;

    Abstract : The objective of the present work is to determine the potential injury-reducing benefits to car occupants in accidents of seat and seat-belt design. The main problems addressed are the risk of injury to head, neck, and upper torso in frontal impacts, and the risk of minor neck-injuries - whiplash-injuries - in rear-end collisions. READ MORE