Search for dissertations about: "receptor antagonism"

Showing result 1 - 5 of 59 swedish dissertations containing the words receptor antagonism.

2. 1. Progesterone metabolites : learning, tolerance, antagonism & metabolism

   Author : Charlotte Öfverman; Inga-Maj Johansson; Torbjörn Bäckström; Esa Korpi; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allopregnanolone; isoallopregnanolone; THDOC; learning; tolerance; antagonism; inhibition; patch clamp; Morris water maze; metabolism; epimerization; Obstetrics and gynaecology; Obstetrik och gynekologi; obstetrik och gynekologi; Obstetrics and Gynaecology;

   Abstract : Progesterone metabolites as allopregnanolone, isoallopregnanolone and tetrahydrodeoxy-corticosterone (THDOC) are increased in the luteal phase of the menstrual cycle, throughout pregnancy and during stress. Allopregnanolone and THDOC are neurosteroids with 3α-hydroxy, 5α-configurations and positive modulating effect on the GABAA receptor. READ MORE

4. 2. Molecular basis of estrogen receptor antagonism

   Author : Nina Heldring; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Estrogen Receptor; antagonism; receptor signaling; phytoestrogen and conformational changes;

   Abstract : Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined effects of accessory proteins, known as coregulators, promoter characteristics and influence from other signaling systems, determine the cell-specific transcriptional response in a given situation. READ MORE

5. 3. Cardiovascular risk factors in renal artery stenosis : Effects of renal angioplasty and angiotensin II receptor antagonism

   Author : Elzbieta Nowakowska-Fortuna; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; renovascular hypertension; endothelin 1; apolipoprtoein C-III; brain natriuretic peptides; angiotensin II receptor antagonism; renal angioplasty; atherosclerotic renal artery stenosis;

   Abstract : Renovascular hypertension (RVH) caused by atherosclerotic renal artery stenosis (ARAS) is one of the most common forms of secondary hypertension. The prognosis for patients with RVH is much worse compared to patients with primary hypertension, and caused by a high cardiovascular morbidity. READ MORE

6. 4. Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

   Author : Charlotta Wallinder; Anders Hallberg; Mathias Alterman; Anders Karlén; Elizabeth E. Sugg; Uppsala universitet; []
   Keywords : AT2 receptor agonist; AT2 receptor antagonist; Ang II peptidomimetics;

   Abstract : The G protein-coupled receptors (GPCRs) are important targets in drug discovery. In several cases, the endogenous ligands that activate the GPCRs of pharmaceutical interest are peptides. READ MORE

7. 5. Endothelin receptor antagonism and hypertonic solutions in experimental endotoxin shock

   Author : Anna Somell; Karolinska Institutet; Karolinska Institutet; []
   Keywords : sepsis; endotoxin; fluid resuscitation; hypertonic saline dextran; endothelin; tezosentan;

   Abstract : Sepsis is a common and serious condition among patients in the intensive care unit. It is characterized by a systemic inflammatory response, resulting in cardiovascular instability and impaired organ tissue oxygenation due to hypoperfusion and inflammatory changes. READ MORE