Search for dissertations about: "receptor degradation"

Showing result 1 - 5 of 190 swedish dissertations containing the words receptor degradation.

  2. 1. Galanin receptor ligands : Design, synthesis, characterization and biological effects

    Author : Kristin Webling; Ülo Langel; Tore Bengtsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Galanin is a 29/30 amino acid long bioactive peptide discovered over 30 years ago when C-terminally amidated peptides were isolated from porcine intestines. The name galanin originates from a combination of the first and last amino acids - G from glycine and the rest from alanine. READ MORE

  4. 2. Ubiquitination and Receptor Endocytosis

    Author : Kaisa Haglund; Carl-Henrik Heldin; Ivan Dikic; Harald Stenmark; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Ubiquitination; receptor tyrosine kinase; endocytosis; Cbl; CIN85; EGFR; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Protein ubiquitination is an evolutionary conserved mechanism that controls a wide variety of cellular functions. Polyubiquitinated proteins are generally degraded in the proteasome, whereas monoubiquitination controls various other cellular processes, including endocytosis and endosomal sorting. READ MORE

  5. 3. Structure and function of the HDL receptor SR-BI : scavenger receptor class B type I

    Author : Magnus S.C. Johnson; Göteborgs universitet; []
    Keywords : SR-BI; HDL; Cholesterol; Scavenger receptor; Apoptosis; Ovary; Gallbladder; Peroxisome;

    Abstract : Low plasma levels of high-density lipoprotein (HDL) and high levels of low-density lipoprotein (LDL) are well-recognized risk factors for cardiovascular disease. The uptake and degradation of LDL cholesterol have been characterized in detail at the molecular level. Less is known about the metabolism and cellular uptake of HDL cholesterol. READ MORE

  6. 4. Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

    Author : Charlotta Wallinder; Anders Hallberg; Mathias Alterman; Anders Karlén; Elizabeth E. Sugg; Uppsala universitet; []
    Keywords : AT2 receptor agonist; AT2 receptor antagonist; Ang II peptidomimetics;

    Abstract : The G protein-coupled receptors (GPCRs) are important targets in drug discovery. In several cases, the endogenous ligands that activate the GPCRs of pharmaceutical interest are peptides. READ MORE

  7. 5. Arthritogenecity of RNA and its degradation products

    Author : Fariba Zare; Göteborgs universitet; []
    Keywords : dsRNA; ssRNA; virus; arthritis; TLR3; IL-1R; IFNalpha beta receptor; plasminogen; tissue factor; uric acid; inflammation; arthritis; neutrophils;

    Abstract : Viral infections often lead to arthralgias and overt arthritic states. Expression of double stranded RNA (dsRNA) is a common feature of all viruses during their replication and it has been suggested that it is able to induce production of pro-inflammatory cytokines, e.g., interferon-alpha (IFN-alpha). READ MORE