Search for dissertations about: "receptor drug design"
Showing result 1 - 5 of 60 swedish dissertations containing the words receptor drug design.
-
1. Design and Synthesis of Novel AT2 Receptor Ligands : From Peptides to Drug-Like Molecules
Abstract : Many peptide receptors are of pharmaceutical interest and there is thus a need for new ligands for such receptors. Unfortunately, peptides are not suitable as orally administrated drugs since they are associated with poor absorption, rapid metabolism and low sub-receptor selectivity. READ MORE
-
2. Design strategies for new drugs targeting multicomponent systems : focusing on class II MHC proteins and acetylcholinesterase
Abstract : The field of medicinal chemistry is constantly evolving. Aided by advances within techniques as well as knowledge of biological systems, increasingly complex targets and drugs can be considered. READ MORE
-
3. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies
Abstract : Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man. The aim of this thesis was to develop nonlinear mixed effects methods for estimation of the relationship between drug exposure and receptor occupancy for the two mGluR5 antagonists AZD9272 and AZD2066 and for the 5HT1B receptor antagonist AZD3783. READ MORE
-
4. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties
Abstract : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. READ MORE
-
5. Computational Modeling of the AT2 Receptor and AT2 Receptor Ligands : Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound Models
Abstract : Rational conversion of biologically active peptides to nonpeptide compounds with retained activity is an appealing approach in drug development. One important objective of the work presented in this thesis was to use computational modeling to aid in such a conversion of the peptide angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe). READ MORE