Search for dissertations about: "receptor occupancy"

Showing result 1 - 5 of 32 swedish dissertations containing the words receptor occupancy.

  1. 1. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Matts Kågedal; Uppsala universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PET; positron emission tomography; receptor occupancy; nonlinear mixed effects; NONMEM; optimal design; dose finding; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Receptor occupancy assessed by Positron Emission Tomography (PET) can provide important translational information to help bridge information from one drug to another or from animal to man. The aim of this thesis was to develop nonlinear mixed effects methods for estimation of the relationship between drug exposure and receptor occupancy for the two mGluR5 antagonists AZD9272 and AZD2066 and for the 5HT1B receptor antagonist AZD3783. READ MORE

  2. 2. Role of the Blood-Brain Barrier in Stereoselective Distribution and Delay in H1 Receptor Occupancy of Cetirizine in the Guinea Pig Brain

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anubha Gupta; Uppsala universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Cetirizine enantiomers; Brain distribution; Microdialysis; H1 receptor occupancy; Stereoselective-pharmacokinetics; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Abstract : Cetirizine, an H1-antihistamine, is prescribed for allergic disorders. It exists as a racemic mixture, with levocetirizine being the active enantiomer. The central nervous system side-effects of H1-antihistamines are caused by their penetration into the brain. READ MORE

  3. 3. Depot neuroleptic maintenance treatment: clinical, pharmacological and neuropsychological aspects

    University dissertation from Psychiatry

    Author : Eva Tuninger; Lunds universitet.; Lund University.; [1997]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; clinical psychology; Psychiatry; laterality.; chronic psychosis; schizophrenia; outcome; maintenance treatment; follow-up; longitudinal; neuropsychology; SPECT; auditory hallucinations; dopamine receptor occupancy; psychosomatics; Psykiatri; klinisk psykologi; psykosomatik;

    Abstract : Popular Abstract in Swedish Underhållsbehandling med neuroleptika minskar risken för nya skov av schizofreni. Ofta har patienter med kronisk psykos bristande sjukdomsinsikt och är därmed dåligt motiverade att följa medicinordinationer (bristande compliance). READ MORE

  4. 4. Population Pharmacodynamic Modeling and Methods for D2-receptor Antagonists

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Klas Petersson; Uppsala universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; population modeling; schizophrenia; D2-antagonists; pharmacodynamics; drug development;

    Abstract : Early predictions of a potential drug candidate’s time-course of effect and side-effects, based on models describing drug concentrations, drug effects and disease progression, would be valuable to make drug development more efficient. Pharmacodynamic modeling can incorporate and propagate prior knowledge and be used for simulations of different scenarios. READ MORE

  5. 5. Modulation of Nuclear Receptor Signaling by RBR Ubiquitin Ligases

    University dissertation from Stockholm : Karolinska Institutet, Dept of Biosciences and Nutrition

    Author : Nina Gustafsson Sheppard; Karolinska Institutet.; Karolinska Institutet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Nuclear receptors (NRs) constitute a superfamily of transcription factors and play important roles in physiology. Transcriptional regulation by NRs can be modulated through interactions with various coregulators that activate or repress transcription through mediating receptor and chromatin modifications as well as communicating with the general transcription factor machinery. READ MORE