Search for dissertations about: "receptor occupancy"

Showing result 6 - 10 of 34 swedish dissertations containing the words receptor occupancy.

  2. 6. PET applications in schizophrenia : Functional and pharmacological dopamine studies

    Author : Ola Gefvert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Schizophrenia; PET; dopamine synthesis rate; dopamine D2 receptor occupancy; atypical antipsychotics; quetiapine; risperidone microsphere depot; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Abstract : Schizophrenia is a group of disorders with a worldwide lifetime prevalence of 0.85%. Thefunctional outcome of the disorder seem stable from the first systematic outcome studies to thepresent day, and vary only with changes in diagnostic criteria. READ MORE

  4. 7. Positron emission tomography studies of the D1-dopamine receptor in schizophrenia

    Author : Per Stenkrona; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis is based on investigations of central D1-dopamine receptor (D1R) binding in vivo using positron emission tomography (PET). The aims were i) to examine the antipsychotic effect of a D1R antagonist in schizophrenia and ii) to test the dopamine hypothesis of schizophrenia by comparing D1R binding between patients and healthy subjects. READ MORE

  5. 8. Dopamine D2 receptor pharmacology : in vitro analyses and in vivo pet imaging

    Author : Mette Skinbjerg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The goals of the present thesis were to study high affinity agonist binding at the D2 dopamine receptor and to explore the role of agonist induced internalization of the receptor in positron emission tomography (PET) imaging studies. For this purpose, we combined in vitro studies of radioligand binding and receptor internalization with in vivo studies in rodents using PET. READ MORE

  6. 9. A PET study on dopamine and serotonin receptor binding in the primate brain : challenges with antipsychotic drugs and amphetamine

    Author : Yuan-Hwa Chou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The brain imaging technique positron emission tomography (PET) has been applied to study dopamine and serotonin neurotransmission. In schizophrenia research, an important observation is that patients with schizophrenia, when compared with controls, have higher amphetamine induced dopamine release in the striatum. READ MORE

  7. 10. Pet imaging of two monoaminergic neurotransmitter systems in brain : studies of the norepinephrine transporter and dopamine D[2] receptor

    Author : Nicholas Seneca; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Positron emission tomography (PET) has been widely used to study non-invasively function of the brain, pathophysiology of disease and aid in the development of new drugs. PET and selective radiolabeled molecules allow imaging of certain critical components of neurotransmission, such as pre-synaptic transporters and post-synaptic receptors in living brain. READ MORE