Search for dissertations about: "receptor oligomerization"
Showing result 1 - 5 of 21 swedish dissertations containing the words receptor oligomerization.
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1. G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
Abstract : The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. READ MORE
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2. The Biophysics of Na+,K+-ATPase in neuronal health and disease
Abstract : Na+,K+-ATPase is one of the most important proteins in the mammalian cell. It creates sodium and potassium gradients which are fundamental for the membrane potential and sodium-dependent secondary active transport. READ MORE
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3. Receptors for growth hormone and prolactin. Regulation and activation
Abstract : Cytokine receptor activation is dependent on ligand-induced receptor dimerization or oligomerization and subsequent activation of several intracellular proteins. Activation of Janus kinases (Jaks) is probably the first intracellular event that occurs after receptor dimerization. READ MORE
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4. Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells
Abstract : Bim is a significant pro-apoptotic member of Bcl-2 family of proteins; it is proved to be an important regulator of apoptosis: over the years it has been shown to play a pivotal role for the development and maintenance of homeostasis in many cellular systems and tissues. The Bcl-2 family of proteins is a group of key regulators of the mitochondrial, or intrinsic, pathway of apoptosis. READ MORE
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5. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity
Abstract : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. READ MORE