Search for dissertations about: "receptor up-regulation"
Showing result 11 - 15 of 123 swedish dissertations containing the words receptor up-regulation.
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11. Dynamic regulation of aryl hydrocarbon receptor function and activity by different stimuli
Abstract : Cells have to sense and adapt to changes in their surrounding environment. Most of the cellular responses to environmental and developmental stimuli are mediated by PAS (Per-ARNT-Sim) proteins. A member of this family of proteins is the aryl hydrocarbon receptor (AhR), a ligand-activated bHLH transcription factor and E3 ubiquitin ligase. READ MORE
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12. Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms
Abstract : Insulin exhibits pleiotropic effects that are tissue- as well as development-dependent. However, the mechanisms by which insulin gains selective effects are poorly understood. Selectivity in insulin signaling is currently discussed as the result of the activation of specific signal transduction pathways. READ MORE
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13. Influence of FK506 on certain aspects of lymphocyte activation and lymphocyte-endothelial cell interactions in vitro
Abstract : In the present thesis, the influence of the immunosuppressive drug FK506 on mitogen-induced changes in the expression of subunits a and ß of the IL-2 receptor by isolated human peripheral blood mononuclear cells has been studied. Up-regulation and release of the a-chain were potently depressed by FK506, even in the presence of exogenous IL-2. READ MORE
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14. Dysregulation of receptor induced apoptosis during human leishmaniasis : a possible mechanism of skin ulceration
Abstract : Leishmaniasis is endemic in 88 countries and 12 million people per year have been estimated to be at risk of infection. The causative agent, the protozoan Leishmania, is spread by sand-flies and infects macrophages in the mammalian host. Leishmaniasis in humans form a spectrum of clinical presentations. In cutaneous leishmaniasis (CL) caused by L. READ MORE
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15. Effects of Inflammatory Mediators on Pulmonary Airways
Abstract : Chronic inflammation is together with excessive contraction of the airways key features of asthma. The aims of the thesis were to analyze the effect of inflammatory mediators on airway smooth muscle, using an in vitro model of cultured murine airways. READ MORE