Search for dissertations about: "receptor-receptor interactions"

Showing result 1 - 5 of 6 swedish dissertations containing the words receptor-receptor interactions.

2. 1. Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction

   Author : Roberto Rimondini-Giorgini; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Adenosine; A; receptors; A2A receptors; dopamine; D1 receptors; D2 receptors; mGluR receptors; striatum; immediately early genes; c-fos; junB; NGFI-A; microdialysis; receptor binding; in situ hybridisation;

   Abstract : The neurotransmitter dopamine seems to be involved in neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Direct blockade of dopamine receptors of the D2 subtype has been the hallmark of pharmacotherapy for schizophrenia since early 1950s. READ MORE

4. 2. Adenosine A2A receptors : characterization, localization, G protein coupling and interactions with dopamine D2 receptors

   Author : Björn Kull; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Adenosine receptors; receptor-receptor interactions; G proteins; species differences;

   Abstract : Adenosine not only has a role in cellular energy metabolism but is recognized as an intercellular messenger with an important function in physiology and pathophysiology. It exerts its effects via a family of G protein coupled receptors of which four members have been cloned from several species: A, A2A, A2B and A3. READ MORE

5. 3. Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects

   Author : Maria Torvinen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Adenosine; adenosine deaminase; A; receptor; A2A receptor; cell line; coimmunoprecipitation; confocal microscopy; dopamine; D1 receptor; D2 receptor; D3 receptor; heteromerization; internalisation; radioligand binding;

   Abstract : The dopamine receptors have been shown to be involved in a variety of higher brain functions, such as motor control, cognition and affective states. Agonist and antagonists of dopamine receptors are widely used to treat disorders such as Parkinson's disease and schizophrenia, respectively. READ MORE

6. 4. Reciprocal interactions of neuropeptide y and angiotensin II receptors with a2-adrenoceptors in the nucleus tractus solitarii of the rat

   Author : Shao-Nian Yang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Neuropeptide Y angiotensin II adrenaline noradrenaline; clonidinereceptor receptor-receptor interaction cardiovascular control immediate earlygene microinjection quantitative receptor autoradiographyimmunocytochemistry in situ hybridization ~ ;

   Abstract : Neuropeptide Y (NPY), angiotensin II (Ang II) and adrenergic transmission lines in the nucleus tractus solitarii (NTS), the major relay nucleus involved in the cardiovascular reflex, play an important role in central cardiovascular control. The present work explored reciprocal interactions of NPY and Ang II receptor subtypes with a2-adrenoceptors in the NTS of the normotensive Sprague-Dawley rat (SD), the normotensive Wistar Kyoto rat (WKY) and the spontaneously hypertensive rat (SHR) by using a cardiovascular analysis, quantitative receptor autoradiography, immunocytochemistry and in situ hybridization techniques. READ MORE

7. 5. Interactions between the opioid and serotonin systems in chronic pain : quantitative live cell study by fluorescence cross-correlation spectroscopy (FCCS)

   Author : Vlad Radoi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Chronic pain is a major health issue worldwide. It enacts considerable suffering on the affected individuals and significantly increases the societal burden, as it is the most common reason why individuals seek sick leave and ask for medical help. READ MORE