Search for dissertations about: "recombinant antibody production"

Showing result 1 - 5 of 60 swedish dissertations containing the words recombinant antibody production.

  2. 1. Systems enabling antibody-mediated proteomics research

    Author : Ronny Falk; Sophia Hober; Christer Wingren; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody generation; dual expression; affinity purification; E. coli expression; Affibody molecules; polyclonal antibody; monospecific antibody; Immunobiology; Immunbiologi;

    Abstract : As many genome sequencing efforts today are completed, we are now provided with the genetic maps for several organisms, including man. With these maps at hand, the scientific focus is now shifting towards investigations of the functionality of proteins. READ MORE

  4. 2. Engineering yeast for improved recombinant protein production

    Author : Yanyan Wang; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; point mutation; genome-scale modeling; recombinant protein; omics analysis; CRISPR Cas9; protein secretion; Saccharomyces cerevisiae;

    Abstract : Recombinant proteins are broadly used from basic research to therapeutic development and include industrial enzymes and pharmaceutical proteins. The increasing demand for improved production and enhanced quality of recombinant proteins requires robust biotech-based strategies to overcome the limitations of protein extraction from natural sources. READ MORE

  5. 3. Production and delivery of recombinant subunit vaccines

    Author : Christin Andersson; KTH; []
    Keywords : Affibody; Affinity chromatography; Affinity purification; DNA immunization; Expression plasmid; Fusion protein; Hydrophobic tag; Iscoms; Lipid tagging; Malaria; Mammalian cell expression; Recombinant immunogen; Respiratory Syncytial Virus; Semliki Fo;

    Abstract : Recombinant strategies are today dominating in thedevelopment of modern subunit vaccines. This thesis describesstrategies for the production and recovery of protein subunitimmunogens, and how genetic design of the expression vectorscan be used to adapt the immunogens for incorporation intoadjuvant systems. READ MORE

  6. 4. Recombinant subunit vaccines : protein immunogens

    Author : Sissela Liljeqvist; KTH; []
    Keywords : ;

    Abstract : Recombinant techniques provide valuable tools for thedevelopment of modern subunit vaccines. In this thesisdifferent systems for production of recombinant subunitvaccines are presented. The strategies investigated includeprotein immunogens, live bacterial vectors and nucleicacids. READ MORE

  7. 5. Regulation of antibody production in immunocompromised patients

    Author : Anna Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hypergammaglobulinemia; specific antibodies; memory B- cells; microenvironment;

    Abstract : The aim of this thesis was to study B-cell function and the regulation of specific antibody (Abs) production in immunocompromised individuals. As models, we have studied children with acute lymphoblastic leukaemia (ALL) and patients with IRV-I infection. READ MORE