Search for dissertations about: "recombinant dna vaccine"

Showing result 1 - 5 of 35 swedish dissertations containing the words recombinant dna vaccine.

  2. 1. Heat shock proteins as vaccine adjuvants

    Author : Khaleda Rahman Qazi; Carmen Fernández; Qijun Chen; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heat shock protein; vaccine; adjuvant; BCG; Immunology; Immunologi;

    Abstract : New efficient vaccines against infectious diseases are in demand. Some important factors impeding the vaccine development are the poor immunogenicity and the MHC restriction of the immune responses to a number of antigens. READ MORE

  4. 2. Production and delivery of recombinant subunit vaccines

    Author : Christin Andersson; KTH; []
    Keywords : Affibody; Affinity chromatography; Affinity purification; DNA immunization; Expression plasmid; Fusion protein; Hydrophobic tag; Iscoms; Lipid tagging; Malaria; Mammalian cell expression; Recombinant immunogen; Respiratory Syncytial Virus; Semliki Fo;

    Abstract : Recombinant strategies are today dominating in thedevelopment of modern subunit vaccines. This thesis describesstrategies for the production and recovery of protein subunitimmunogens, and how genetic design of the expression vectorscan be used to adapt the immunogens for incorporation intoadjuvant systems. READ MORE

  5. 3. Recombinant subunit vaccines : protein immunogens

    Author : Sissela Liljeqvist; KTH; []
    Keywords : ;

    Abstract : Recombinant techniques provide valuable tools for thedevelopment of modern subunit vaccines. In this thesisdifferent systems for production of recombinant subunitvaccines are presented. The strategies investigated includeprotein immunogens, live bacterial vectors and nucleicacids. READ MORE

  6. 4. Alphavirus vectors as recombinant vaccines

    Author : Peter Berglund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Semliki Forest virus; Alphavirus; Synthetic vaccmes; Influenza A virus; HIV-I; SIV; DNA vaccines; AIDS vaccines; Influenza vaccine;

    Abstract : This thesis describes further developments of an expression system based on the alphavirus Semliki Forest virus (SFV), and its potential use as recombinant vaccine. The RNA genome of SFV contains a 3'open reading frame (ORF) encoding the structural proteins, and a 5' ORF coding for the viral replicase. READ MORE

  7. 5. Enhancement of HIV-1 DNA immunogens

    Author : Anne Kjerrström Zuber; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; DNA vaccination; regulatory genes; adjuvants; experimental HIV-1 model;

    Abstract : Human immunodeficiency virus type 1 eludes control by the immune response through a high degree of variability and immune escape mechanisms. Induction of a broad specific immune response is important to clear virus-infected cells. READ MORE