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Showing result 1 - 5 of 50 swedish dissertations matching the above criteria.

  2. 1. Peroxiredoxins in Redox Signaling and Aging

    Author : Friederike Roger; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Aging; Peroxiredoxin; Redox Signaling; Caloric restriction; light sensing;

    Abstract : Peroxiredoxins have emerged as conserved modulators of the rate of aging in yeast and multicellular organisms and play a role in lifespan extension through the anti-aging intervention caloric restriction. Yet, it is not clear through what mechanism peroxiredoxins extend lifespan. READ MORE

  4. 2. DNA checkpoint override and redox signaling in Schizosaccharomyces pombe

    Author : Johanna J Sjölander; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Caffeine; Cell cycle; Checkpoint; Cdc25; Wee1; TORC1; FHIT; Proliferation; Aph1; Redox; Hypoxia; H2O2; Cysteine; Thiol; Allosteric; MAPK; Sty1; MAPKK; Wis1;

    Abstract : This thesis covers intracellular stress signaling through genotoxic stress, overriding of checkpoint control, as well as cellular redox status in hypoxic and oxidative stress Papers I and II: Caffeine has been shown to override cell cycle checkpoints in humans as well as in the fission yeast Schizosaccharomyces pombe. Understanding of the mechanism may aid in the development of compounds with similar overriding mechanisms for sensitization in cancer therapy. READ MORE

  5. 3. Intricate aspects of the thioredoxin system in redox signaling

    Author : Marcus Cebula; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Reversible modifications of redox sensitive protein thiols by reactive oxygen and nitrogen species have emerged as a major posttranslational mechanism that affects the function of the respective proteins and therewith all downstream events. These modifications can be reversed by redox catalysts of which the thioredoxin system forms one of the most prominent. READ MORE

  6. 4. PTPs : redox controlled regulators of cell signaling and transformation

    Author : Åsa Sandin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Protein tyrosine phosphatases (PTPs) are important redox regulated enzymes that control the tyrosine phosphorylation status in the cell. These studies aimed to increase the understanding on how PTPs are controlled by reversible oxidation in different pathological settings such as hypoxia and restenosis and to which extent oxidized PTPs contribute to certain diseases. READ MORE

  7. 5. Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling

    Author : Markus Dagnell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Protein tyrosine phosphatases (PTPs) are reversibly oxidized upon activation of platelet-derived growth factor receptor beta (PDGFβR). Dys-regulation of the PDGFβR signaling pathway is associated with several diseases, including cancers and cardiovascular disease, and is thus a known driver of disease progression. READ MORE