Search for dissertations about: "redox signaling"

Showing result 16 - 20 of 50 swedish dissertations containing the words redox signaling.

2. 16. Modulation of cytochrome c release by mitochondrial redox status and caspase-2

   Author : Mari Enoksson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Apoptosis; cytochrome c release; mitochondria; Glutaredoxin; glutathione;

   Abstract : The release of cytochrome c is an important event during apoptosis, induced by diverse stimuli. Our laboratory has previously proposed that cytochrome c release occurs via a two-step process, involving the detachment of the hemoprotein from its binding to the inner mitochondrial membrane, followed by its release into the cytosol through pores in the outer mitochondrial membrane - an event that is usually triggered by proapoptotic Bcl-2 family proteins, such as Bid, Bax and Bak. READ MORE

4. 17. Urocortins in the zebrafish brain and redox regulation of embryonic development through glutaredoxins

   Author : Lars Bräutigam; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The cellular redox state is a central regulator of embryonic development. Redox homeostasis and thiol redox signaling are modulated through glutaredoxins (Grxs), glutathione dependent thiol-disulfide oxidoreductases. Grxs can reduce protein disulfides and protein-glutathione mixed disulfides (de-glutathionylation) via distinct reaction mechanisms. READ MORE

5. 18. Experimental and clinical studies on liver regeneration and hepatocellular carcinoma : roles of redox proteins, iron homeostasis and multikinase inhibition

   Author : Annelie Mollbrink; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Compensatory liver regeneration is triggered by chronic liver injury or surgery and is crucial to maintain tissue homeostasis. The underlying mechanisms which include a whole battery of complex signaling events have been thoroughly studied for decades. READ MORE

6. 19. Functional characterization of cytosolic and mitochondrial thioredoxin reductases

   Author : Ivan Nalvarte; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Thioredoxin; thioredoxin reductase; reactive oxygen species; mitochondria; differentiation; redox signaling; ubiquinone; cytochrome c; selenium; selenoprotein.;

   Abstract : Mammalian thioredoxin reductases (TrxRs) are homodimeric selenoproteins belonging to the nucleotide oxidoreductase family. They contain a C-terminal penultimate selenocysteine residue, which is kept reduced by the N-terminal redox active site, CVNVGC, of the adjacent subunit. READ MORE

7. 20. Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants

   Author : Anna-Klara Rundlöf; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Redox regulation; thioredoxin reductase; TXNRD1; selenoprotein; promoter; transcription; alternative splicing; expression;

   Abstract : Reactive oxygen species are generated in cells as by-products of aerobic metabolism. To protect from damaging effects the cells possess several antioxidant systems and one of the most important is the thioredoxin system. READ MORE