Search for dissertations about: "redox-active compounds"

Showing result 1 - 5 of 17 swedish dissertations containing the words redox-active compounds.

  2. 1. C–H and Si–H functionalization using redox-active diazo compounds and decarboxylative coupling

    Author : Rajdip Chowdhury; Abraham Mendoza; Darren Dixon; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; carbenes; radicals; redox-active esters; indoles; carboxylic acids; silanes; photochemistry; Organic Chemistry; organisk kemi;

    Abstract : The work presented in this thesis is based on two basic organic chemistry concepts: carbene catalysis and radical coupling reactions. Diazo compounds in the presence of transition-metal catalysts are known to be excellent reagents for the construction of C–X bonds (X = C, Si, N, O, etc.) under mild conditions. READ MORE

  4. 2. Asymmetric Synthesis using Redox-Active Diazocompounds as Chiral Carbon Atom Precursors

    Author : Matteo Costantini; Abraham Mendoza; Armido Studer; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; redox-active carbenes; mechanistic investigation; cyclopropanes; asymmetric catalysis; photochemistry; organisk kemi; Organic Chemistry;

    Abstract : This thesis summarizes the development of general and efficient methods to synthesize enantiomerically enriched cyclopropane compounds. The works reported herein exploit the opportunity presented by redox-active esters to explore the orthogonality between asymmetric carbene-transfer and geminal radical generation. READ MORE

  5. 3. Selenium compounds as a novel class of experimental cancer chemotherapeutics

    Author : Arun Kumar Selvam; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Selenium is an essential micronutrient for humans, it has a narrow margin between antioxidant and pro-oxidant effects. Redox-active selenium compounds have the potency to increase ROS levels in cancer cells, providing a plausible window for therapeutic intervention. READ MORE

  6. 4. Proton trapping in the cellular acidic vacuolar compartment : lysosomal mechanisms in apoptosis/necrosis and iron chelation

    Author : Zhengquan Yu; Anders Isaksson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Under ischemic conditions, a number of cytotoxic metabolic products are formed. Reactive oxygen species are known to be important mediators of progressive ischemic cell injury, and the synergistic damage to cells caused by the combination of such oxygen species and redox-active iron is well appreciated. READ MORE

  7. 5. Selenium cytotoxicity in cancer

    Author : Marita Wallenberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Selenium is an essential trace element, present in the 21st amino acid selenocysteine, which is specifically incorporated into selenoproteins. Today, there are 25 identified selenoproteins in humans, whereof many comprises redox active functions to uphold the intracellular redox balance. READ MORE