Search for dissertations about: "refolding"
Showing result 21 - 25 of 27 swedish dissertations containing the word refolding.
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21. Selective induction of apoptosis in tumors by small molecules reactivating p53
Abstract : Lesions in the p53 pathway that inactivate p53 tumor suppression function occur with extremely high frequency in cancer, targeting almost all tumors regardless of patient age or tumor type. This study is aimed at developing approaches for the selective elimination of tumors carrying defects in the p53 pathway, namely protection of p53 from degradation by its own destructor HDM2 in wild type p53-carrying tumors and refolding of p53 by small molecules in mutant p53-containing tumors. READ MORE
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22. Determining the effects of regulatory parameters on the structural dynamics of P-type ATPase membrane transporters
Abstract : Proteins are macromolecular machines with roles in all cellular activities and structures. The functional properties of each protein is the result of its combination of 3D-structure and inherent dynamics, and a wealth of structural and dynamic mechanisms have evolved to regulate protein activity. READ MORE
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23. Structural studies of MHC class 1 complexes : implications for NK- and T-cell recognition
Abstract : The cell-cell recognition events and the functional characteristics of the cell surface receptors that govern the responses of NK- and T-cells are central to molecular immunology. This thesis addresses the structural basis of such molecular recognition, more specifically the interaction between peptides and MHC class I molecules, as well as the interaction between such complexes and the inhibitory Ly49 receptors of NK cells or triggering antigen specific receptors of T-cells (TCR). READ MORE
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24. Paleoproterozoic deformation in the Kiruna‑Gällivare area in northern Norrbotten, Sweden : Setting, character, age, and control of iron oxide-apatite deposits
Abstract : This thesis covers the structural evolution of the Kiruna‑Gällivare area in the northern Norrbotten ore province, Sweden. The study area hosts several economically significant iron oxide-apatite (IOA) deposits and includes the type locality for this ore type. READ MORE
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25. Genetic design for facilitated production of human peptide hormones inEscherichia coli
Abstract : Genetic strategies have become important in the design ofefficient processes for production of recombinant proteins.When constructing a production scheme, inherent properties,purity and quality requirements, as well as the final use ofthe protein, have to be considered. READ MORE