Search for dissertations about: "region-specific properties"
Showing result 1 - 5 of 7 swedish dissertations containing the words region-specific properties.
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1. Human neural stem cells: region-specific properties and prospects for cell therapy
Abstract : Cell replacement by neural transplantation can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. READ MORE
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2. In vivo properties of neural stem cells after transplantation into the rat brain-Studies of phenotypic differentiation and functional integration using cell-specific labelling and electrophysiological techniques
Abstract : In the present thesis, we have examined the in vivo properties of in vitro expanded human and rat neural stem-and progenitor cells after transplantation into the neonatal and adult rat brain. The survival and differentiation of the grafted cells were assessed using species-specific antisera, and pre-labelling with the reporter gene green fluorescent protein (GFP). READ MORE
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3. Maintenance of neuronal identity and function
Abstract : Neurons in the CNS acquire specific characteristics throughout development and maintain them for the entire lifespan. Instructive regulation of the transcription machinery ensures the acquisition of identity by spatiotemporal patterns of transcription factor expression. READ MORE
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4. Stem cell based therapy of malignant brain tumors
Abstract : Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. READ MORE
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5. Ethanol-induced modulation of dopamine transmission and synaptic activity in striatal subregions - focus on inhibitory receptors
Abstract : Background: Alcoholism is a chronic brain disease, affecting neurocircuitries involved in reward and learning. The rewarding effects of alcohol (ethanol) are believed to result from increased dopamine levels in the nucleus accumbens (nAc) via the mesolimbic system. READ MORE