Search for dissertations about: "regulation of steroid levels"

Showing result 1 - 5 of 76 swedish dissertations containing the words regulation of steroid levels.

  2. 1. Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels

    Author : Hanna Pettersson; Maria Norlin; Kjell Wikvall; Paolo Parini; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP27A1; CYP7B1; cytochrome P450; estrogen receptor; androgen receptor; cholesterol; sex hormone; hydroxylation; steroid metabolism; regulation of steroid levels; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : The enzymes CYP27A1 and CYP7B1 are widely expressed in various human tissues and perform catalytic reactions in cholesterol homeostasis and endocrine signaling. We have investigated the metabolism of a synthetic oxysterol. READ MORE

  4. 2. Hormonal Regulation of Vaginal Mucosa

    Author : Theodora Kunovac Kallak; Anneli Staverus-Evers; Inger Sundström Poromaa; Philippa Saunders; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aromatase inhibitors; vaginal atrophy; estrogen; proliferation; steroid hormone receptors; cell differentiation; cell adhesion; aquaporin 3;

    Abstract : Vaginal atrophy symptoms such as dryness, irritation, and itching, are common after menopause. Vaginal estrogen therapy is the most effective treatment but not appropriate for all women. READ MORE

  5. 3. Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation : Special Focus on Vitamin D and Sex Hormones

    Author : Johan Lundqvist; Kjell Wikvall; Maria Norlin; Magnus Ingelman-Sundberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenal steroidogenesis; CYP7B1; vitamin D; calcitriol; enzymatic regulation; transcriptional regulation; CYP21A2; aromatase; sex hormone; estrogen; androgen; nuclear receptor; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : Enzyme-catalyzed reactions are important to regulate steroidogenesis and nuclear receptor activation. The present investigation examines the role of steroid metabolism catalyzed by CYP7B1 for regulation of hormone receptor activation and the effects of vitamin D on enzymatic regulation of steroidogenesis. READ MORE

  6. 4. GABA-steroid effects in healthy subjects and women with polycystic ovary syndrome

    Author : Helena Hedström; Torbjörn Bäckström; Marie Bixo; Ian Milsom; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; isoallopregnanolone; gonadotropins; GABA-A receptor; women; polycystic ovary syndrome; saccade; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background: The progesterone metabolite allopregnanolone is involved in several clinical conditions in women, e.g. premenstrual dysphoric disorder. It is a very potent GABA-steroid with GABA-A receptor effects similar to other GABA-agonists, e. READ MORE

  7. 5. Molecular studies of dyslexia : regulation and function of DYX1C1

    Author : Kristiina Tammimies; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Developmental dyslexia is a specific reading disability characterized by unexpected difficulty in reading and writing despite adequate intelligence, education, normal senses and social environment. It is the most common childhood learning disorder affecting five to ten percent of school age children and it is more common among boys than girls. READ MORE