Search for dissertations about: "regulatory peptides"

Showing result 21 - 25 of 76 swedish dissertations containing the words regulatory peptides.

  2. 21. Free Fatty Acid Receptor 2 - A G protein coupled receptor with unique signaling properties in neutrophils

    Author : Simon Lind; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neutrophils; G protein coupled receptors; Free Fatty Acid Receptor 2; GPR43; Allosteric modulation; Transactivation; Cross-talk; Biased signalling; Functional selectivity;

    Abstract : The overall aim of the PhD thesis was to determine the role of neutrophil pattern recognition receptors in the initiation and resolution of inflammatory processes. Neutrophil pattern recognition receptors such as the formyl peptide receptors (FPRs) and the short free fatty acid receptors (FFARs) belong to the family of G protein coupled receptors (GPCR). READ MORE

  4. 22. Influence of MHC class I peptide interaction on antigen presentation in normal and malignant cells

    Author : Qian-Jin Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cytotoxic T lymphocytes; Natural Killer cells; Epstein-Barr virus; MHC class I; class I binding motifs; T cell receptor; antigen presentation; immunodominance;

    Abstract : The presentation of MHC class I peptide complexes in normal and malignant cells was studied. An HLA A11 binding motif was defined by comparing synthetic peptide analogues of a known cytotoxic T Iymphocyte (CTL) target epitope for induction of surface A11 expression and triggering of cytotoxic activity. READ MORE

  5. 23. Modulation of HIV immune responses in natural infection and after genetic immunization

    Author : Sandra Amelia Calarota; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Identification and treatment of HIV-1 infection are both urgent, in view of the continued spread of the infection. We developed easy and inexpensive serological methods for the diagnosis and follow-up of children born to HIV-1-infected mothers. A quantitative immunofluorescence method replaced the cumbersome Western blot. READ MORE

  6. 24. Molecular basis for the MHC class II association in rat experimental autoimmune encephalomyelitis

    Author : Katrien L de Graaf; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis investigates the functional and structural aspects of rat MHC class 11 molecules and studies their influence on MBP- and MOG-peptide induced experimental autoimmune encephalomylitis (EAE) in LEW MHC congenic rat strains. EAE is an animal model for multiple sclerosis (MS) and can be induced in rats with components of the myelin sheath . READ MORE

  7. 25. A study of the cytoplasmic domains of C-CAM isoforms : calmodulin binding and phosphorylation

    Author : Magnus Edlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : adhesion molecules; adhesion regulation; BGP; Bgp; biliary glycoprotein; Calcium; Calmodulin; CaM; CAMs; carcinoembryonic antigen gene family; C-CAM; CEA; cell adhesion; Immunoglobulin super-family; PKC; protein kinase C.;

    Abstract : C-CAM, a member of the Immunoglobulin Superfamily, was originally identified as an intercellular adhesion molecule, and can mediate cell-cell adhesion by homophilic binding. However, it also appears in high concentrations in luminal, microvillar surfaces. READ MORE