Search for dissertations about: "regulatory toxicology"

Showing result 21 - 25 of 32 swedish dissertations containing the words regulatory toxicology.

  2. 21. The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function

    Author : Ulrika Mårtensson; Drug Target Discovery; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; HIV SIV; TIG2 chemerin; transcriptional regulation; ligand activation; Co-receptor; GPCR; ChemR23 CMKLR1;

    Abstract : In all higher organisms, there is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. READ MORE

  4. 22. Systemic and local regulation of experimental arthritis by IFN-α, dendritic cells and uridine

    Author : Sudeep Chenna Narendra; Mattias Magnusson; Srinivas Uppugunduri; Alf Kastbom; Natacha Bessis; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : In this thesis, we have studied the immunological processes of joint inflammation that may be targets for future treatment of patients with arthritis. We focus on the immune-modulating properties of interferon-α (IFN-α) and uridine in experimental arthritis. READ MORE

  5. 23. Glucagon-like peptide-1 and alcohol-mediated behaviors in rodents

    Author : Daniel Vallöf; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addiction; Dopamine; Gut-brain axis; Reward;

    Abstract : Alcohol use disorder (AUD) is a serious cause of morbidity and mortality. However, due to the limited efficacy of existing pharmacotherapies, further investigations of potential neurochemical targets are required to define new pharmacological interventions. READ MORE

  6. 24. Impact of epidemiologically identified mixtures of endocrine disrupting chemicals on metabolic programming

    Author : Polina Lizunkova; Joëlle Rüegg; Elin Engdahl; Joachim Sturve; Carl-Gustaf Bornehag; Juliette Legler; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Endocrine disrupting chemicals; Mixtures; Metabolism; Developmental Toxicology; Epigenetics; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Abstract : We are ubiquitously exposed to a plethora of endocrine-disrupting chemicals (EDCs), i.e. substances that alter the function(s) of the endocrine system. While ample evidence show individual EDC's influence on developmental processes resulting in adverse health outcomes, less is known about the effects of human-relevant EDC mixtures exposure. READ MORE

  7. 25. Does acetylcholin play a role in mitosis of V79 Chinese hamster cells?

    Author : Cecilia Söderpalm-Berndes; Stephen M Wolniak; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; toxikologisk genetik; Genetic Toxicology;

    Abstract : The first stages of mitosis are governed by a cascade of phosphorylations brought about by the universal MPF kinase complex. From a regulatory point of view, less is known about late mitotic events. READ MORE