Search for dissertations about: "replacement"

Showing result 16 - 20 of 987 swedish dissertations containing the word replacement.

2. 16. Exploring Patient-Specific Cell Replacement Therapy for Parkinson's Disease

   Author : Shelby Shrigley; Utvecklings- och regenerativ neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopaminergic neurons; Parkinson s disease; cell replacement therapy; cellular reprogramming; alpha-synuclein;

   Abstract : Parkinson’s disease (PD) affects over six million people worldwide and is characterised by the progressive loss of dopaminergic (DA) neurons in the substantia nigra, accumulation of pathological alpha-synuclein (αSyn), and inflammation in the brain. This leads to motor impairments including rigidity, akinesia, bradykinesia, resting tremor, and postural instability. READ MORE

4. 17. Psychological distress and contentment after primary total knee replacement

   Author : Aamir Mahdi; Per Wretenberg; Maria Hälleberg-Nyman; Olof Sköldenberg; Örebro universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anxiety; contentment; depression; discontentment; psychological distress; patients’ expectations; total knee replacement;

   Abstract : The overall aim of this thesis was to study patients with anxiety/depression symptoms before and after primary total knee replacement, particularly in terms of improvements in patients-reported outcomes, and particularly among those who were discontent with the surgery. This could hopefully improve patients' contentment after TKR. READ MORE

5. 18. Novel strategies for enzyme replacement with gene therapy in models of Parkinson’s disease

   Author : Erik Cederfjäll; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AAV vectors; dopamine; enzyme replacement; gene regulation; GTP cyclohydrolase 1; L-DOPA; tyrosine hydroxylase; Parkinson’s disease;

   Abstract : Parkinson’s disease is a brain disorder characterized by loss of dopaminergic neurons in the midbrain, resulting in the characteristic motor symptoms: resting tremor, rigidity, akinesia and postural instability. Symptomatic treatment is based on reconstituting the loss of dopamine in the brain, primarily by oral administration of its precursor L-DOPA. READ MORE

6. 19. Clinical and immunological aspects of IgG subclass deficiency : Predictors for the need of immunoglobulin replacement therapy

   Author : Per Wågström; Charlotte Dahle; Sofia N. Nyström; Åsa Nilsdotter-Augustinsson; Mats Nilsson; Ola Winqvist; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunoglobulin G subclass deficiency; inflammation; lymphocytes; fatigue; co-morbidity; immunoglobulin G replacement therapy;

   Abstract : Background: Predominantly antibody deficiencies (PAD) are inborn errors of immunity, and associate with increased susceptibility to infections. Life-long immunoglobulin replacement therapy (IgRT) is introduced based on Ig-levels and the frequencies and severity of infections. READ MORE

7. 20. Non-functioning pituitary adenomas and hypopituitarism - studies on morbidity and mortality

   Author : Casper Hammarstrand; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-functioning pituitary adenomas; Hypopituitarism; Glucocorticoid replacement; Growth hormone replacement; Morbidity; Mortality; Cancer; LDL-cholesterol;

   Abstract : Background and aims: Hypopituitarism is most commonly caused by benign pituitary tumors, often resulting in insidious symptoms that develop over a long time. Due to either a mass effect exerted by the tumor, or due to the surgical treatment, hormonal deficiencies may arise, requiring hormone replacement. READ MORE