Search for dissertations about: "replicative viruses"

Showing result 1 - 5 of 7 swedish dissertations containing the words replicative viruses.

  2. 1. Co-evolution of the HIV-1 R5 phenotype and the viral envelope glycoproteins

    Author : Johanna Repits; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; envelope; R5; HIV-1; evolution;

    Abstract : To gain entry into target cells, HIV-1 binds to CD4 via the viral glycoprotein gp120. This interac-tion initiates a series of events including binding of a coreceptor, CCR5 and/or CXCR4, and ulti-mately leads to gp41-mediated fusion of the viral and cell membranes. READ MORE

  4. 2. Nora virus as a model to study persistent infection in Drosophila melanogaster

    Author : Mazen Habayeb; Dan Hultmark; Joachim De Miranda; Molecular Biology; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nora virus; Drosophial; persistence; transmission; RNAi; capsid proteins; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar; molekylärbiologi; Molecular Biology;

    Abstract : Drosophila melanogaster has been widely used as a model organism to study the immune responses against bacteria, fungi, parasites and viruses. Here, I present a D. melanogaster virus as a model to study persistent virus infections. I have discovered and characterized the Nora virus, a small picorna-like RNA virus able to persistently infect D. READ MORE

  5. 3. Intrahost evolution of HIV-1 phenotypes

    Author : Marie Borggren; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : HIV-1 evolves constantly within an infected individual, due to its mutation-prone viral enzyme, high viral turnover and pressure from the host immune system. Therefore, viruses isolated at different time points from the same individual are never exactly the same and, accordingly, rarely function the same way. READ MORE

  6. 4. Biological correlates of HIV-1 heterosexual transmission

    Author : José Ramón Fiore; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1 sexual transmission HIV-1 biological phenotypelneutralizing antibodies V3 loop antibodies infectiousness disease progression drug resistance;

    Abstract : HIV-1 infection is a sexually transmitted disease but HIV transmission efficiency by sexual contacts appears to be highly variable; this is probably due to the influence that several behavioural, clinical and biological factors exert on the transmission event. Here we focused on possible biological correlates of HIV sexual transmission, with emphasis on the host antibody response towards HIV and the virus biological characteristics. READ MORE

  7. 5. Studies on early cellular responses during Epstein-Barr virus infection

    Author : Xinsong Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human gamma-herpesvirus Epstein-Barr virus (EBV) has been implicated in the pathogenesis of a broad spectrum of lymphoid and epithelial cell malignancies. A characteristic property of the virus is the capacity to establish a non-productive growthpromoting infection in B-lymphocytes. READ MORE