Search for dissertations about: "replisome"

Showing result 1 - 5 of 11 swedish dissertations containing the word replisome.

  2. 1. Dynamic Organization of Molecular Machines in Bacteria

    Author : Bhupender Singh; Santanu Dasgupta; Leif A. Kirsebom; Don G. Ennis; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecular machines; bacteria; cell cycle; ribosome; replisome; divisome; spore; E. coli; H. pylori; Mycobacteria; Microbiology; Mikrobiologi; Mikrobiologi; Microbiology;

    Abstract : Bacterial cells were once treated as membrane-enclosed bags of cytoplasm: a homogeneous, undifferentiated suspension in which polymers (proteins, nucleic acids, etc.) and small molecules diffused freely to interact with each other. READ MORE

  4. 2. Functional and structural characterization of the human mitochondrial helicase

    Author : Jenny Korhonen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mitochondria; mtDNA; replication; replisome; TWINKLE; mtSSB; POL g ; adPEO.;

    Abstract : Mitochondria are the energy producing organelles of the eukaryotic cell. The human mitochondrial DNA (mtDNA) is a double stranded circular molecule of about 16 kb, usually present at 1000-10 000 copies per cell. The genome encodes 13 polypeptides involved in respiration, two ribosomal RNA s and a set of 22 transfer RNA s. READ MORE

  5. 3. Insights into the roles of the essential Pfh1 DNA helicase in the nuclear and mitochondrial genomes

    Author : Parham Pourbozorgi Langroudi; Nasim Sabouri; Anders Hofer; Per Sunnerhagen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G4; genome integrity; Pfh1; Top1; helicase; topoisomerase; replication; transcription;

    Abstract : Eukaryotic cells have two sets of genomes, the nuclear and mitochondrial, and both need to be accurately maintained. Also, the rate of transcription must be precisely regulated in these genomes. However, there are many natural barriers that dysregulate these processes. READ MORE

  6. 4. Molecular insights into mitochondrial DNA replication

    Author : Javier Miralles Fusté; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mitochondria are organelles found in eukaryotic cells. These organelles produce most of the adenosine triphosphate that cells use as a source of energy. Mitochondria contain their own genomic material, a circular DNA genome (mtDNA) that encodes subunits of the respiratory chain complexes and RNA components needed for mitochondrial translation. READ MORE

  7. 5. DNA precursor biosynthesis-allosteric regulation and medical applications

    Author : Reza Rofougaran; Anders Hofer; Thomas Borén; Staffan Eriksson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; DNA biosynthesis; ribonucleotide reductase; allosteric regulation; Trypanosoma brucei; adenosine kinase; nucleoside analogs; mitochondrial DNA; TWINKLE; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Abstract : Ribonucleotide reductase (RNR) is a key enzyme for de novo dNTP biosynthesis. We have studied nucleotide-dependent oligomerization of the allosterically regulated mammalian RNR using a mass spectrometry–related technique called Gas-phase Electrophoretic Mobility Macromolecule Analysis (GEMMA). READ MORE