Search for dissertations about: "reproducible assays"

Showing result 1 - 5 of 16 swedish dissertations containing the words reproducible assays.

  2. 1. Alpha-class Glutathione Transferases from Pig: a Comparative Study

    Author : Natalia Fedulova; Bengt Mannervik; Francoise Raffalli-Mathieu; Mario Lo Bello; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; glutathione transferase; substrate selectivity; steroidogenesis; Sus scrofa; functional comparison; irreproducibility; reproducible assays; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : Glutathione transferases (GSTs, EC 2.5.1.18) possess multiple functions and have potential applications in biotechnology. READ MORE

  4. 2. Development and biomedical applications of highly sensitive enzyme activity assays of thioredoxin, thioredoxin reductase and glutaredoxin

    Author : Sergio J Montano; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oxidative stress is implicated in the pathogenesis of many human diseases, thus it is interesting to study the relationship between antioxidants, the development and progression of diseases. The thioredoxin and glutaredoxin systems are ubiquitous redox-active proteins known to be induced in chronic inflammatory related processes, such as cancer and diabetes, to protect against oxidative stress. READ MORE

  5. 3. Amino acid sequence and side chain specific synthetic receptors targeting protein phosphorylation

    Author : Anil Incel; Frank Kjeldsen; Malmö universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; imprinted polymers; synthetic receptors; PTM; phosphorylation; enrichment; diagnosis;

    Abstract : Antibodies have become a critical component of many diagnostic assays and are used for therapeutic purposes. Nevertheless they often fail to meet the strict performance demands raised in industry and in the clinic (e.g. stability, reproducibility, selectivity, affinity). READ MORE

  6. 4. Integrating extrinsic and intrinsic cues to guide cell fate decisions : rational approaches in stem cell engineering

    Author : Jamie Mong; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The long-term goal of stem cell engineering is to generate functional cells for cell replacement therapies, disease modelling and in drug development assays. It is evident that one of the major challenges in stem cell research is to develop reproducible methods to obtain well-defined and pure populations of clinically relevant cell types in a sustainable manner. READ MORE

  7. 5. Studies on methotrexate and cladribine : bioanalytical, pharmacokinetic, and clinical aspects

    Author : Freidoun Albertioni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of these studies was to delineate the pharmacokinetics of methotrexate (MTX) and cladribine in order to improve the basis for individualization and optimization of treatment with these two antimetabolites. Methodological aspects of MTX assays in clinical routine usage were investigated as plasma MTX determinations are mandatory in the high-dose treatment of childhood acute Iymphoblastic leukemia (ALL). READ MORE