Search for dissertations about: "resampling"

Showing result 1 - 5 of 31 swedish dissertations containing the word resampling.

  2. 1. Statistical analysis and simulation methods related to load-sharing models

    Author : Patrik Rydén; Yuri Belyaev; Uwe Jensen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Non-parametric and parametric estimation; load-sharing models; asymptotic distribution; martingale; resampling; life testing; reliability;

    Abstract : We consider the problem of estimating the reliability of bundles constructed of several fibres, given a particular kind of censored data. The bundles consist of several fibres which have their own independent identically dis-tributed failure stresses (i.e.the forces that destroy the fibres). READ MORE

  4. 2. Algorithmic discovery, development and personalized selection of higher-order drug cocktails : A label-free live-cell imaging & secretomics approach

    Author : Efthymia Chantzi; Mats G Gustafsson; Ulf Hammerling; Andreas Bender; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug combination discovery and development; personalized pharmacotherapy; higher-order drug combination analysis; quantitative label-free live-cell imaging; secretomics; cell-cell communication; deep learning; convolutional neural networks; data mining; MapReduce; resampling; generalized highest single agent; COMBImageDL; COMBSecretomics; Bioinformatics; Bioinformatik; Pharmacology; Farmakologi; Engineering Science; Teknisk fysik;

    Abstract : An upward trend in clinical pharmacology is the use of multiple drugs to combat complex and co-occurring diseases due to better efficacy, decreased toxicity and reduced risk of evolving resistance. Despite high late-stage attrition rates and the need for multi drug treatments, most drug discovery and development efforts are still mainly focused on new one-size-fits-all monotherapies. READ MORE

  5. 3. Electromagnetic Field Induced Out-of-Equilibrium Structural Dynamics in Protein Crystals: From Picoseconds to Milliseconds

    Author : Viktor Ahlberg Gagnér; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Terahertz radiation; low frequency vibrations; B-factors; ADP tensor; bovine trypsin; FemtoMAX; resampling; femtosecond structural dynamics; millisecond structural dynamics; LCLS; displacements; distances; photosynthetic reaction center;

    Abstract : Light-induced interactions in biomolecules are strongly varying over different model systems. Most amino acids and proteins absorb ultraviolet light, but only a few with specialised chromophores or fluorophores, are able to absorb light in the visible spectrum. READ MORE

  6. 4. Organization of information pathways in complex networks

    Author : Atieh Mirshahvalad; Martin Rosvall; Santo Fortunato; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Complex systems; Complex Networks; Information; Communication; Community Detection; Significance Analysis; Resampling; Information Spreading.; computer and systems sciences; data- och systemvetenskap;

    Abstract : A shuman beings, we are continuously struggling to comprehend the mechanism of dierent natural systems. Many times, we face a complex system where the emergent properties of the system at a global level can not be explained by a simple aggregation of the system's components at the micro-level. READ MORE

  7. 5. Dynamic Resampling for Preference-based Evolutionary Multi-objective Optimization of Stochastic Systems : Improving the efficiency of time-constrained optimization

    Author : Florian Siegmund; Kalyanmoy Deb; Amos H.C. Ng; Sanaz Mostaghim; Högskolan i Skövde; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Evolutionary multi-objective optimization; simulation-based optimization; guided search; preference-based optimization; reference point; decision support; noise; stochastic systems; dynamic resampling; budget allocation; sequential sampling; hybrid; ranking and selection; Natural sciences; Naturvetenskap; Technology; Teknik; Production and Automation Engineering; Produktion och automatiseringsteknik;

    Abstract : In preference-based Evolutionary Multi-objective Optimization (EMO), the decision maker is looking for a diverse, but locally focused non-dominated front in a preferred area of the objective space, as close as possible to the true Pareto-front. Since solutions found outside the area of interest are considered less important or even irrelevant, the optimization can focus its efforts on the preferred area and find the solutions that the decision maker is looking for more quickly, i. READ MORE