Search for dissertations about: "response of chemotherapy in ovarian cancer"

Showing result 1 - 5 of 22 swedish dissertations containing the words response of chemotherapy in ovarian cancer.

  2. 1. Hunting a Silent Killer. Biomolecular Approaches in Ovarian Cancer

    Author : Nicolai Arildsen; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ovarian cancer; Molecular biology; genetic variant; TP53 mutation; early detection; Drug Screening Assays; Antitumor; bioinformatics; next generation sequencing; NGS; prognostic and predictive biomarkers; ovarian clear cell cancer; high-grade serous ovarian cancer;

    Abstract : Ovarian cancer is a heterogeneous disease and recent advances in improving patient outcome havebeen limited. It is estimated that a woman’s risk of developing ovarian cancer during her lifetime is about 1 in 70, making it a frequently occurring cancer type in women. READ MORE

  4. 2. Ovarian cancer : Treatment results, prognostic factors, and tumor marker surveillance

    Author : Thomas Högberg; Claes Tropé; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The total population-based material of 426 ovarian malignancies in the Southeast Health Care Region of Sweden during 1984-1987 was surveyed. It seems that with a program of cytoreductive surgery followed by a cisplatinum chemotherapy combination in the metastasizing cases the overall survival figures have improved. READ MORE

  5. 3. Pharmacogenetic Studies of Paclitaxel in Ovarian Cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics

    Author : Henrik Green; Curt Peterson; Peter Söderkvist; Per Rosenberg; Håkan Melhus; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacogenetics; paclitaxel; LC MS; Taxol; ovarian cancer; pharmacokinetics; CYP2C8; CYP3A4; ABCB1; äggstockscancer; paklitaxel; Clinical pharmacology; Klinisk farmakologi;

    Abstract : Ovarian cancer is one of the most common female cancer diseases in the world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. READ MORE

  6. 4. Exploring Cancer Drugs In Vitro and In Vivo : With Special Reference to Chemosensitivity Testing and Early Clinical Development

    Author : Anne von Heideman; Peter Nygren; Bengt Tholander; Rolf Larsson; Seija Grénman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic drug; in vitro assay; drug development; phase I clinical trial; Oncology; Onkologi; Oncology; Onkologi;

    Abstract : The aims of this thesis were to investigate the utility of in vitro drug sensitivity testing to optimize the use of cancer chemotherapy and to assess the properties of a new cancer drug in a phase I clinical trial. Tumour cells from patients were analysed with the short-term Fluorometric Microculture Cytotoxicity Assay (FMCA). READ MORE

  7. 5. Characterization of genetic alterations in ovarian cancer associated with chemotherapy response

    Author : Lovisa Österberg; Göteborgs universitet; []
    Keywords : Oncology; ovarian cancer; chemotherapy resistance; predictive markers;

    Abstract : Ovarian cancer is the most lethal of all gynecological malignancies, and exhibit an overall fiveyear survival rate of only 48% in Sweden. The high mortality in ovarian cancer is largely due to late diagnosis and chemotherapy resistance. READ MORE