Search for dissertations about: "responsive regulation"

Showing result 11 - 15 of 138 swedish dissertations containing the words responsive regulation.

  2. 11. Hfq- and sRNA-mediated regulation in Neisseria meningitidis

    Author : Jens Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neisseria meningitidis, also known as the meningococcus, is a human-specific pathogen that commonly colonises the nasopharynx without causing disease. For reasons unknown, N. meningitidis can traverse the nasopharyngeal epithelium and enter the bloodstream, causing invasive meningococcal disease manifesting in septicaemia and/or meningitis. READ MORE

  4. 12. Genetic polymorphism and regulation of cytochrome P450 2E1

    Author : Yin Hu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytochrome P450 2E1 (CYP2E1) participates in the metabolism of several xenobiotics. A physiological role of CYP2E1 is its ability to convert acetone into gluconeogenetic precursors. Due to a pronounced oxidase activity CYP2E1 can generate substantial amount of oxygen free radicals and may contribute to oxidative stress. READ MORE

  5. 13. Gene regulation by nuclear hormone receptors in vivo

    Author : Anethe Mansén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The nuclear hormone receptor superfamily contains 49 different members, including those for thyroid hormone, TR? and TR?. These receptors are ligand-modulated transcription factors that activate or repress gene activity. The TR? gene encodes two main splice variants, TR?1 and TR?2. READ MORE

  6. 14. LXR regulation of hepatic gene expression and pituitary dependent hormones

    Author : Pia Kotokorpi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Liver X receptor; growth hormone; gene regulation; metabolism; hepatocyte; hepatic steatosis; species differences;

    Abstract : The liver X receptors (LXRs) are ligand activated transcription factors involved in the regulation of metabolic genes. LXRs are considered potential drug targets to treat metabolic disorders, however, unwanted side effects, as revealed from rodent studies, include increased lipogenesis in the liver and increased plasma triglyceride levels. READ MORE

  7. 15. Regulation of cytochrome P4502C7 : effects of growth hormone and vitamin A

    Author : Stefan Westin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : P450; growth hormone; vitamin A; gene regulation; orphan receptors;

    Abstract : Members of the CYP2C subfamily, highly represented in rat liver, are constitutively expressed genes that encode enzymes that metabolize endogenous substrates such as steroids. Expression of P4502C11 and P4502C12 in rat liver is regulated in a sex-specific manner that ultimately depends on the sexually differentiated secretory pattern of GH release. READ MORE