Search for dissertations about: "resveratrol"

Showing result 1 - 5 of 16 swedish dissertations containing the word resveratrol.

  2. 1. Mechanisms and time course of cell death in embryonic nigral tissue and intrastriatal transplants

    Author : Mia Emgård; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypothermia; resveratrol; free radicals; ultrastructure; electron microscopy; mesencephalic; transplantation; rat; Parkinson s disease; dopamine; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and severely affects about one in a hundred persons over the age of fifty years. In PD, there is a reduced striatal concentration of the neurotransmittor dopamine, mainly caused by a degeneration of the dopaminergic neurons in the substantia nigra. READ MORE

  4. 2. The impact of glucotoxicity on pancreatic β-cell function

    Author : Sarheed Jabar Muhammed; Islet cell physiology; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP PKA system; iNOS; Type 2 diabetes; GSIS; PDE; GK rat; ZDF fa fa rat; GPR40; VDAC1; VDAC2; GSK-3β; ChREBP; TXNIP; resveratrol.;

    Abstract : Type 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. READ MORE

  5. 3. Synthesis of Small Molecules Targeting ADP-Ribosyltransferases and Total Synthesis of Resveratrol Based Natural Products

    Author : Anders Lindgren; Mikael Elofsson; Nicholas Westwood; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic synthesis; quinazolinone; ARTD; PARP; total synthesis; polyphenols; bensofuranes; organisk kemi; Organic Chemistry;

    Abstract : Diphtheria Toxin-like ADP-RibosyltransferasesThe Human ADP-ribosyl transferases (ARTDs) are a group of poorly studied enzymes which are believed to be involved in e.g. DNA repair, protein degradation, transcription regulation and cell death. Medicinal chemistry programmes aimed at developing selective inhibitors of these ARTDs were initiated. READ MORE

  6. 4. Angiogenesis in obesity and cancer

    Author : Ebba Bråkenhielm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adiponectin; endothelial cells; Leptin; Resveratrol; TNP-470;

    Abstract : Angiogenesis is the process of blood vessel growth from pre-existing vasculatures. In the adult, it is involved in certain physiological processes, such as in organ and tissue regeneration, wound healing, and in female reproductive cycles. READ MORE

  7. 5. Diverse effects of endocrine-disruptive chemicals on Leydig and adrenocortical cell steroidogenesis in rodents and humans

    Author : Iuliia Savchuk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : We are living in a man-made world and often exposed to different chemicals known as endocrine disrupting chemicals (EDCs) that negatively influence our hormonal system. These compounds have the potential to interrupt a normal steroidogenesis and result in harmful effects on the reproductive health of humans and among other organisms. READ MORE