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Showing result 1 - 5 of 14 swedish dissertations matching the above criteria.

  2. 1. Experimental porcine models of retinal ischemia

    Author : Håkan Morén; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal ischemia; animal model; multifocal electroretinography; intraarterial coiling; retinal vasculature;

    Abstract : Retinal ischaemia resulting from e.g. diabetes, vein thrombosis or arterial occlusion, is one of the major causes of visual impairment and blindness. Although new methods of treatment are being developed, there is still a need for more effective pharmacological forms of treatment. READ MORE

  4. 2. Effects of Ischaemia on the Neuroretina and Retinal Blood Vessels

    Author : Bodil Gesslein; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein kinase C; tumor necrosis factor; mitogen-activated protein kinases; pig; blood vessels; mfERG; Retinal ischaemia; vascular endothelial growth factor; hypoxia-inducible factor;

    Abstract : Identification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. READ MORE

  5. 3. Functional genomics of vascular endothelial cells

    Author : Elisabet Wallgard; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Vasculature; endothelial cells; angiogenesis; vascular endothelial growth factor VEGF ; Notch; transcriptome; genomics; microarray; tumor; retina; morpholino knockdown;

    Abstract : Angiogenesis, the formation of new blood vessels from preexisting ones, is a process involved in normal development as well as in several pathological conditions, such as cancer, ischemic heart disease, wound healing and certain retinal complications. Antiangiogenic targeting is therefore a promising new therapeutic principle. READ MORE

  6. 4. The role of endoglin in vascular patterning and malformation across diverse vascular beds

    Author : María García Collado; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During development, numerous processes must be finely orchestrated to construct a functional vasculature, essential to sustain life. Hereditary haemorrhagic telangiectasia is a disease characterised by the development of arteriovenous malformations and it is caused in over 80% of the cases by mutations in either endoglin (ENG) or ALK1. READ MORE

  7. 5. Investigation of potential prognostic and therapeutic genes in pathologic neovascularization of the retina

    Author : Parviz Mammadzada; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Karolinska Institutet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Pathologic angiogenesis of the retina is a hallmark of frequent blinding conditions among the elderly, such as proliferative diabetic retinopathy (PDR) and neovascular age-related macular degeneration (nAMD). The underlying mechanisms are complex. READ MORE