Search for dissertations about: "retinal vasculature"

Showing result 6 - 10 of 14 swedish dissertations containing the words retinal vasculature.

  2. 6. Cdc42, orchestrator of vascular morphogenesis in the retina

    Author : Alberto Álvarez-Aznar; Konstantin Gängel; Christer Betsholtz; Taija Mäkinen; Ondine Cleaver; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cdc42; endothelial cell; pericyte; mural cell; angiogenesis; CreERT2; Medicinsk vetenskap; Medical Science;

    Abstract : Cdc42 is a small GTPase that controls many cellular functions related to cytoskeletal dynamics, such as migration, polarity, and proliferation. Despite what we know of Cdc42 in other cell types, not much research has been done on the vasculature. READ MORE

  4. 7. The Role of Paladin in Endothelial Cell Signaling and Angiogenesis

    Author : Anja Nitzsche; Mats Hellström; Frank-Dietmar Böhmer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pald1; endothelium; lung; vascular permeability; phosphatase; angiogenesis; Molekylär medicin; Molecular Medicine;

    Abstract : Angiogenesis, the formation of new blood vessels from a pre-existing vasculature, is crucial during development and for many diseases including cancer. Despite tremendous progress in the understanding of the angiogenic process, many aspects are still not fully elucidated. READ MORE

  5. 8. Role of extracellular retention of platelet-derived growth factor-B. Functions in development and disease

    Author : Per Lindblom; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; pericyte; cancer; fibrosis; ECM; HSPG; cell retention; endothelial;

    Abstract : During development, the cell secretes growth and differentiation factors (GDFs) to the surrounding microenvironment. These factors are often key regulators of organogenesis and embryogenesis. Several GDFs carry sequences that mediate specific interaction with molecules of the extracellular matrix (ECM) that surrounds the cell. READ MORE

  6. 9. The impact of vascular structure and function on tumor growth, retinopathy, and antiangiogenic therapy

    Author : Eva-Maria Hedlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tumors produce multiple angiogenic factors to stimulate neovascularization that is essential for tumor growth, invasion and metastasis. Despite the known angiogenic functions of each individual factor, the interplay between these angiogenic factors in the tumor local environment and in modulation of the host functions remain poorly understood. READ MORE

  7. 10. Investigating mechanisms of angiogenesis in health and disease using zebrafish models

    Author : Zaheer Ali; Lasse D. Jensen; Neil Lagali; Massimo Santoro; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Angiogenesis, the growth of blood vessels from an existing vasculature, can occur by sprouting from preexisting vessels or by vessel splitting (intussusception). Pathological angiogenesis drives choroidal neovascularization (CNV) in age related macular degeneration (AMD) which is commonly restricted under the retinal pigment epithelium (RPE), called occult CNV, but may also involve vessels penetrating through the RPE into the sub-retinal space. READ MORE