Search for dissertations about: "retinoic acid."

Showing result 31 - 35 of 129 swedish dissertations containing the words retinoic acid..

  2. 31. Epigenetic gene regulation in multiple myeloma and mood disorders

    Author : Antonia Kalushkova; Fredrik Öberg; Helena Jernberg-Wiklund; Lucia Cavelier; Anthony Wright; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IKKα; retinoic acid receptor; multiple myeloma; Polycomb; Ouabain; mood disorders;

    Abstract : Epigenetics continues to be redefined and new discoveries are likely to revolutionise the field still further. This thesis explores different aspects of how epigenetic regulation of gene expression contributes to human disease. READ MORE

  4. 32. In vitro cellular models for neurotoxicity studies : neurons derived from P19 cells

    Author : Dina Popova; Jacobsson Stig O.P.; Anna Forsby; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurotoxicity; Neuronal cell culture; P19 cells; SH-SY5Y cells; βIII-tubulin; Methylmercury; Okadaic acid; Acrylamide; MDMA; Piperazine-derived designer drugs.;

    Abstract : Humans are exposed to a variety of chemicals including environmental pollutants, cosmetics, food preservatives and drugs. Some of these substances might be harmful to the human body. READ MORE

  5. 33. Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer

    Author : Astrid Bengtsson; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF alpha; COX-2; interferon alpha; all-trans retinoic acid; EGF; inflammation; colorectal cancer; CysLT2R; Leukotriene; CysLT1R;

    Abstract : Colorectal cancer is the third most common type of cancer, and the second leading cause of cancer-related deaths in the Western world. Chronic inflammation, such as inflammatory bowel diseases (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. READ MORE

  6. 34. Retinoid metabolism and signalling in vascular smooth muscle cells

    Author : Pauline Ocaya; Allan Sirsjö; Andreas C. Gidlöf; William S. Blaner; Örebro universitet; []
    Keywords : all-trans Retinol; all-trans Retinoic acid; retinoid metabolism; proliferation; Vascular smooth muscle cells; CYP26; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

    Abstract : Smooth muscle cells (SMCs) play a major role in cardiovascular diseases. In advanced atherosclerosis, blood flow is impaired due to reduced luminal diameter. Percutaneous vascular interventions, including balloon angioplasty and stent-application are commonly used for the re-establishment of luminal size and improvement of tissue perfusion. READ MORE

  7. 35. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

    Author : Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

    Abstract : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. READ MORE