Search for dissertations about: "retroviral gene transfer"

Showing result 1 - 5 of 16 swedish dissertations containing the words retroviral gene transfer.

  2. 1. Retroviral gene transfer to repopulating hematopoietic cells

    Author : Thomas Relander; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GLVR-1; VSV-G; amphotropic; GALV; long-term bone marrow culture; NOD SCID; retroviral vector; hematopoietic stem cells; stem cells; gene transfer; gene therapy; fibronectin; Clinical genetics; Klinisk genetik;

    Abstract : Hematopoietic stem cells (HSCs) have the capacity to maintain hematopoiesis throughout life. HSCs are ideal targets for permanent gene transfer, as the transgene will be expressed in all the progeny of the gene-modified stem cells. READ MORE

  4. 2. Vector development for suicide gene therapy

    Author : Alar Aints; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Suicide gene therapy; VP22; selection markers; Ouabain resistance gene; GvHD; retroviral gene transfer;

    Abstract : Gene therapy is used to treat conditions that arise from errors in the genetic makeup of cells either congenital diseases resulting from a deletion or mutation in a gene or malignant diseases where genetic regulation mechanisms have been deranged. Suicide gene therapy is one of several gene therapeutic approaches to treat cancer. READ MORE

  5. 3. Stem cell transplantation in multiple myeloma : clinical aspects and experimental gene transfer studies

    Author : Bo Björkstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : multiple myeloma; bone marrow transplantation; allogeneic; autologous; prognostic factors; hemato-poietic stem eells; gene therapy; gene transfer; retrovirus; basic fibroblast growth factor;

    Abstract : Multiple myeloma (MM) is a hematological malignant disease considered essentially incurable despite its sensitivity to cytotoxic chemotherapeutic drugs and radiation. High-dose chemo/radiotherapy with allogeneic- or autologous hematopoietic stem cell transplantation (tx) can induce a disease-free state and may prolong survival and offer an improved quality of life to MM patients. READ MORE

  6. 4. Semliki forest virus-derived packaging system for production of retroviral vectors

    Author : Ke-Jun Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Moloney murine leukemia virus; Semliki Forest virus; gene therapy; retroviral vector; intron; human bone marrow stromal cell;

    Abstract : Gene therapy is a treatment of disease by transfer of genetic material into somatic cells of an individual. Successful gene therapy depends on a delivery system which can efficiently transfer the gene into target cells and lead to high level expression of the gene. READ MORE

  7. 5. Experimental gene therapy with special reference to plasma cell tumors

    Author : M Sirac Dilber; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Gene therapy may open new perspectives in the treatment of numerous hematopoietic and metabolic disorders. Particularly, hematopoietic cells are very attractive targets for retroviral mediated gene transfer. READ MORE