Search for dissertations about: "reverse genetics"

Showing result 16 - 20 of 37 swedish dissertations containing the words reverse genetics.

  2. 16. Initiation of bacteriophage P2 rolling circle replication

    Author : Richard Odegrip; Barbara Funnel; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Virus; DNA; Genetics; genetik;

    Abstract : Viruses are very simple entities. In its most simple form, the virus consists of a protein shell containing genetic material. To propagate the virus needs a host to parasitize, in which it can replicate its genetic material and assembly new virus particles. Viruses that parasitize bacteria are termed bacteriophages. READ MORE

  4. 17. Whole Genome Sequencing of Enterotoxigenic Escherichia coli

    Author : Astrid von Mentzer; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ETEC; whole genome sequencing; evolution; colonization factor; reverse genetics;

    Abstract : Enterotoxigenic Escherichia coli (ETEC) infections are a common cause of diarrhea but little is known about the evolution and genomic composition of ETEC. The main aim of this thesis was to generate a large collection of whole genome sequenced ETEC isolates to study the evolution of such bacteria on a global level and to search for novel colonization factors (CFs) using both classical and cutting-edge genomic techniques. READ MORE

  5. 18. UDP-sugar metabolizing pyrophosphorylases in plants : formation of precursors for essential glycosylation-reactions

    Author : Daniel Decker; Leszek A. Kleczkowski; Henrik Vibe Schelle; Umeå universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chemical library screening; Cell wall synthesis; Glycosylation; Nucleotide sugars; Oligomerization; Protein structure; Reverse chemical genetics; Sugar activation; UDP-sugar synthesis; biokemisk farmakologi; biochemical pharmacology; biokemi; Biochemistry; biology; biologi; molekylärbiologi; Molecular Biology;

    Abstract : UDP-sugar metabolizing pyrophosphorylases provide the primary mechanism for de novo synthesis of UDP-sugars, which can then be used for myriads of glycosyltranferase reactions, producing cell wall carbohydrates, sucrose, glycoproteins and glycolipids, as well as many other glycosylated compounds. The pyrophosphorylases can be divided into three families: UDP-Glc pyrophosphorylase (UGPase), UDP-sugar pyrophosphorylase (USPase) and UDP-N-acety lglucosamine pyrophosphorylase (UAGPase), which can be discriminated both by differences in accepted substrate range and amino acid sequences. READ MORE

  6. 19. Identification of Arthritis Regulating Genes in Rats

    Author : Peter Olofsson; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; transplantation; Clinical genetics; Klinisk genetik; serology; Immunology; QTL; RA; Epistasis; Ncf1; Linkage; PIA; Arthritis; Rat;

    Abstract : The immune response is designed to protect the body from harmful microbial invasions. However, when the immune system attacks itself instead, an autoimmune reaction starts that damage our own cells, tissues and organs. READ MORE

  7. 20. Hybridization and Evolution in the Genus Pinus

    Author : Baosheng Wang; Xiao-Ru Wang; Sally Aitken; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Adaptation; biogeography; coalescent simulation; cytoplasmic genome; demographic history; genetic diversity; hybridization; migration; Pinus; population structure; selection; speciation; evolutionär genetik; evolutionary genetics;

    Abstract : Gene flow and hybridization are pervasive in nature, and can lead to different evolutionary outcomes. They can either accelerate divergence and promote speciation or reverse differentiation. The process of divergence and speciation are strongly influenced by both neutral and selective forces. READ MORE