Search for dissertations about: "rhabdomyosarcoma"
Showing result 1 - 5 of 13 swedish dissertations containing the word rhabdomyosarcoma.
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1. Somatic Genetic Variation in Children: from Mosaicism to Cancer
Abstract : This thesis concerns various aspects of somatic mosaicism and genetic intratumor heterogeneity in childhood cancer.In paper I, I show that aneuploidy in itself does not lead to the level of chromosomal instability that is typically seen in malignant cells. This finding strongly argues against the so called autocatalytic theory of carcinogenesis. READ MORE
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2. Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations
Abstract : The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. READ MORE
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3. Hedgehog signaling in rhabdomyosarcoma : role of GLI factors and splice variants in signal transduction
Abstract : Rhabdomyosarcoma (RMS) is the most common soft-tissue childhood cancer. Deregulation of the Hedgehog (HH) signaling pathway, which is essential for proper embryonic development, has been implicated as a driving force for this cancer. READ MORE
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4. Nestin : filament formation and expression in myogenesis and muscle disorders
Abstract : Intermediate filaments (IF), together with microfilaments and microtubules, are the major components of the cytoskeleton of eukaryotic cells. In myogenic cells three IF proteins are expressed; desmin, vimentin and nestin. READ MORE
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5. Fine needle aspiration cytology in diagnosis and management of childhood small round cell tumours
Abstract : Fine needle aspiration (FNA) cytology is accepted for diagnosing malignant tumours in adults. However, it has been slow in gaining acceptance among paediatricians and has only been used at some centres in the routine diagnosis of childhood tumours. READ MORE